A comprehensive review of mRNA vaccines

V Gote, PK Bolla, N Kommineni, A Butreddy… - International journal of …, 2023 - mdpi.com
mRNA vaccines have been demonstrated as a powerful alternative to traditional
conventional vaccines because of their high potency, safety and efficacy, capacity for rapid …

PLGA/PLA-based long-acting injectable depot microspheres in clinical use: production and characterization overview for protein/peptide delivery

A Butreddy, RP Gaddam, N Kommineni… - International journal of …, 2021 - mdpi.com
Over the past few decades, long acting injectable (LAI) depots of polylactide-co-glycolide
(PLGA) or polylactic acid (PLA) based microspheres have been developed for controlled …

Exosomes as naturally occurring vehicles for delivery of biopharmaceuticals: insights from drug delivery to clinical perspectives

A Butreddy, N Kommineni, N Dudhipala - Nanomaterials, 2021 - mdpi.com
Exosomes as nanosized vesicles are emerging as drug delivery systems for therapeutics
owing to their natural origin, their ability to mediate intercellular communication, and their …

Rationally Tailored Mesoporous Hosts for Optimal Protein Encapsulation

F Sha, H Xie, FA Son, KS Kim, W Gong… - Journal of the …, 2023 - ACS Publications
Proteins play important roles in the therapeutic, medical diagnostic, and chemical catalysis
industries. However, their potential is often limited by their fragile and dynamic nature …

[HTML][HTML] Ionic liquids as protein stabilizers for biological and biomedical applications: A review

NV Veríssimo, FA Vicente, RC de Oliveira… - Biotechnology …, 2022 - Elsevier
Biotechnology has revolutionized science and health care by providing new biomolecules
with biological and medical applications. However, the low stability of several life-saving …

Instability challenges and stabilization strategies of pharmaceutical proteins

M Akbarian, SH Chen - Pharmaceutics, 2022 - mdpi.com
Maintaining the structure of protein and peptide drugs has become one of the most important
goals of scientists in recent decades. Cold and thermal denaturation conditions …

Polymer-mediated Protein/Peptide Therapeutic Stabilization: Current Progress and Future Directions

RP Sivasankaran, K Snell, G Kunkel, P Georgiou… - Progress in Polymer …, 2024 - Elsevier
Proteins and peptides have played a pivotal role in revolutionizing disease treatment over
the last century. Despite their commercial success, protein therapeutics can be eliminated or …

Ionic liquids and deep eutectic solvents for the stabilization of biopharmaceuticals: a review

NVP Veríssimo, CU Mussagy, HBS Bento… - Biotechnology …, 2024 - Elsevier
Biopharmaceuticals have allowed the control of previously untreatable diseases. However,
their low solubility and stability still hinder their application, transport, and storage. Hence …

Exploring the diverse applications of Carbohydrate macromolecules in food, pharmaceutical, and environmental technologies

K Ramaprabha, V Kumar, P Saravanan… - Environmental …, 2024 - Elsevier
Carbohydrates are a class of macromolecules that has significant potential across several
domains, including the organisation of genetic material, provision of structural support, and …

Improving effect of disaccharides and maltodextrin on preparation of egg yolk powder by microwave-assisted freeze-drying: Functional properties, structural properties …

Z Wang, X Duan, G Ren, J Guo, J Ji, Y Xu, W Cao, L Li… - Food Chemistry, 2023 - Elsevier
The preparation of egg yolk powder (EYP) with excellent solubility and high retention of
active IgY is of great significance for increasing the added value and promoting the …