Chemistry and biology in the biosynthesis and action of thyroid hormones
S Mondal, K Raja, U Schweizer… - Angewandte Chemie …, 2016 - Wiley Online Library
Thyroid hormones (THs) are secreted by the thyroid gland. They control lipid, carbohydrate,
and protein metabolism, heart rate, neural development, as well as cardiovascular, renal …
and protein metabolism, heart rate, neural development, as well as cardiovascular, renal …
Antithyroid drugs and their analogues: synthesis, structure, and mechanism of action
Thyroid hormones are essential for the development and differentiation of all cells of the
human body. They regulate protein, fat, and carbohydrate metabolism. In this Account, we …
human body. They regulate protein, fat, and carbohydrate metabolism. In this Account, we …
Novel thyroid hormone analogues, enzyme inhibitors and mimetics, and their action
Thyroid hormones (THs) play key roles in modulating the overall metabolism of the body,
protein synthesis, fat metabolism, neuronal and bone growth, and cardiovascular as well as …
protein synthesis, fat metabolism, neuronal and bone growth, and cardiovascular as well as …
Synthesis, characterization and antioxidant activity of angiotensin converting enzyme inhibitors
Angiotensin converting enzyme (ACE) catalyzes the conversion of angiotensin I (Ang I) to
angiotensin II (Ang II). ACE also cleaves the terminal dipeptide of vasodilating hormone …
angiotensin II (Ang II). ACE also cleaves the terminal dipeptide of vasodilating hormone …
Recent developments in the chemistry of NHC-based selones: syntheses, applications and reactivity
Selones, since their first report in 1963, have attracted significant interest with respect to their
bonding, structure and more importantly as an ancillary ligand for complexation with various …
bonding, structure and more importantly as an ancillary ligand for complexation with various …
Inhibition of peroxynitrite-and peroxidase-mediated proteintyrosine nitration by imidazole-based thiourea and selenourea derivatives
KP Bhabak, K Satheeshkumar, S Jayavelu… - Organic & Biomolecular …, 2011 - pubs.rsc.org
In the present study, the synthesis and characterization of a series of N-methylimidazole-
based thiourea and selenourea derivatives are described. The new compounds were also …
based thiourea and selenourea derivatives are described. The new compounds were also …
Selenization of Small Molecule Drugs: A New Player on the Board
There is an urgent need to develop safer and more effective modalities for the treatment of a
wide range of pathologies due to the increasing rates of drug resistance, undesired side …
wide range of pathologies due to the increasing rates of drug resistance, undesired side …
Role of the Solvent in the Reactivity of Bis-4-imidazoline-2-selone Derivatives toward I2: An Experimental and Theoretical Approach
The reactivity of 1, 1′-bis (3-methyl-4-imidazolin-2-selone) methane (L1) and 1, 2-bis (3-
methyl-4-imidazolin-2-selone) ethane (L2) toward I2 has been explored in MeCN under …
methyl-4-imidazolin-2-selone) ethane (L2) toward I2 has been explored in MeCN under …
H2O2-responsive mPEG-2-mercapto-1-methylimidazole prodrug nanosystem for enhanced therapeutic efficacy against hyperthyroidism
Y Dai, D Zheng, Y Zhao, W Wei, X Wu, H Dai - European Polymer Journal, 2025 - Elsevier
Methimazole (MMI) is a widely used anti-hyperthyroidism drug. To improve the therapeutic
effect of MMI and reduce its side effects on thyroid and liver, a new hydrogen peroxide (H 2 …
effect of MMI and reduce its side effects on thyroid and liver, a new hydrogen peroxide (H 2 …
Reactive selenium species: Redox modulation, antioxidant, antimicrobial and anticancer activities
Since its discovery 200 years ago, in 1817, by Jöns Jacob Berzelius (1779–1848), the
element selenium has had a rather chequered relationship with biology and medicine, an …
element selenium has had a rather chequered relationship with biology and medicine, an …