Tumour cells can adopt telomere maintenance mechanisms (TMMs) to avoid telomere
shortening, an inevitable process due to successive cell divisions. In most tumour cells …

A family history of melanoma greatly increases the risk of developing cutaneous melanoma,
a highly aggressive skin cancer whose incidence has been steadily increasing worldwide …

Background Previous genome-wide association studies (GWAS) have identified 42 loci (P<
5× 10− 8) associated with risk of colorectal cancer (CRC). Expanded consortium efforts …

Even distinct cancer types share biological hallmarks. Here, we investigate polygenic risk
score (PRS)-specific pleiotropy across 16 cancers in European ancestry individuals from the …

Telomere length has been associated with risk of many cancers, but results are inconsistent.
Seven single nucleotide polymorphisms (SNPs) previously associated with mean leukocyte …

Background Telomeres are essential for chromosomal integrity and stability. Shortened
telomere length (TL) has been associated with risk of cancers and aging-related diseases …

Genome-wide association studies have reported 56 independently associated colorectal
cancer (CRC) risk variants, most of which are non-coding and believed to exert their effects …

Colorectal cancer (CRC) is the third most common cancer in economically developed
countries and a major cause of cancer-related mortality. The importance of lifestyle and diet …

Purpose: EGF receptor (EGFR) mutation–positive (EGFRmut+) non–small cell lung cancer
(NSCLC) may be a unique orphan disease. Previous studies suggested that the telomerase …

Background: Telomere dysfunction triggers cellular senescence and constitutes a driving
force for cancer initiation. Genetic variants in genes involved in telomere maintenance may …