Extended-spectrum β-lactamase (ESBL)-producing Gram-negative pathogens are a major
cause of resistance to expanded-spectrum β-lactam antibiotics. Since their discovery in the …

Klebsiella oxytoca is actually a complex of nine species—Klebsiella grimontii, Klebsiella
huaxiensis, Klebsiella michiganensis, K. oxytoca, Klebsiella pasteurii, Klebsiella …

Metagenomic studies have shown that antibiotic resistance genes are ubiquitous in the
environment, which has led to the suggestion that there is a high risk that these genes will …

Klebsiella pneumoniae carbapenemases (KPCs) were first identified in 1996 in the USA.
Since then, regional outbreaks of KPC-producing K. pneumoniae (KPC-Kp) have occurred …

This article gives a very brief overview of the antibiotic era, beginning from the discovery of
first antibiotics until the present day situation, which is marred by the emergence of hard-to …

Investigations of antibiotic resistance from an environmental prospective shed new light on a
problem that was traditionally confined to a subset of clinically relevant antibiotic‐resistant …

Inactivation of β‐lactam antibiotics by β‐lactamases in bacterial infections is associated with
some of the most serious infectious disease issues that are currently encountered. The …

A new perspective on the topic of antibiotic resistance is beginning to emerge based on a
broader evolutionary and ecological understanding rather than from the traditional …

ABSTRACT A total of 232 isolates of gram-negative bacteria were recovered from mammals,
reptiles, and birds housed at Asa Zoological Park, Hiroshima prefecture, Japan. Forty-nine …

The aim of the present study was to assess the occurrence and molecular diversity of β-
lactamase genes and integrons among Gram-negative ampicillin-resistant bacteria from Ria …