A systematic and comprehensive review on disease-causing genes in amyotrophic lateral sclerosis
E Srinivasan, R Rajasekaran - Journal of Molecular Neuroscience, 2020 - Springer
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder and is characterized by
degeneration and axon loss from the upper motor neuron, that descends from the lower …
degeneration and axon loss from the upper motor neuron, that descends from the lower …
In silico analysis and molecular dynamics simulation of human superoxide dismutase 3 (SOD3) genetic variants
GRC Pereira, ANR Da Silva… - Journal of cellular …, 2019 - Wiley Online Library
Oxidative stress is a major factor in aging processes. Superoxide dismutase 3 (SOD3) plays
a key role in the protection of extracellular oxidative stress. Missense mutations in SOD3 …
a key role in the protection of extracellular oxidative stress. Missense mutations in SOD3 …
Molecular binding response of naringin and naringenin to H46R mutant SOD1 protein in combating protein aggregation using density functional theory and discrete …
E Srinivasan, R Rajasekaran - Progress in biophysics and molecular …, 2019 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a calamitous neurodegenerative disorder
characterized by denervation of upper and lower motor neurons. Numerous hypotheses …
characterized by denervation of upper and lower motor neurons. Numerous hypotheses …
Explicit-solvent molecular dynamics simulations revealed conformational regain and aggregation inhibition of I113T SOD1 by Himalayan bioactive molecules
The accumulation of aberrant superoxide dismutase (SOD1) protein causes a
neurodegenerative disease known as amyotrophic lateral sclerosis (ALS). A mutation in …
neurodegenerative disease known as amyotrophic lateral sclerosis (ALS). A mutation in …
Computational insight into in silico analysis and molecular dynamics simulation of the dimer interface residues of ALS-linked hSOD1 forms in apo/holo states: a …
HD Zaji, B Seyedalipour, HM Hanun, P Baziyar… - 3 Biotech, 2023 - Springer
The aggregation of misfolded SOD1 proteins in neurodegenerative illnesses is a key
pathological hallmark in amyotrophic lateral sclerosis (ALS). SOD1 is stabilized and …
pathological hallmark in amyotrophic lateral sclerosis (ALS). SOD1 is stabilized and …
Biochemical and biophysical properties of the novel ALS-linked hSOD1 mutants: an experimental study accompanied by in silico analysis
N Namadyan, B Seyedalipour, S Hosseinkhani… - Journal of the Iranian …, 2023 - Springer
Familial amyotrophic lateral sclerosis (fALS) is a neurodegenerative disorder; approximately
20% are caused by dominant mutations in the gene encoding Cu/Zn human superoxide …
20% are caused by dominant mutations in the gene encoding Cu/Zn human superoxide …
A Review On Huntington Protein: Insight Into Protein Aggregation and Therapeutic Interventions
E Srinivasan, V Ram… - Current Drug …, 2022 - ingentaconnect.com
Huntington's disease (HD) is a distressing, innate neurodegenerative disease that descends
from CAG repeat expansion in the huntingtin gene causing behavioral changes, motor …
from CAG repeat expansion in the huntingtin gene causing behavioral changes, motor …
Computer analysis of the relation between hydrogen bond stability in SOD1 mutants and the survival time of amyotrophic lateral sclerosis patients
NA Alemasov, VS Timofeev, NV Ivanisenko… - Journal of Molecular …, 2022 - Elsevier
Background and objective Mutations in the SOD1 protein can lead to the death of motor
neurons, which, in turn, causes an incurable disease called amyotrophic lateral sclerosis …
neurons, which, in turn, causes an incurable disease called amyotrophic lateral sclerosis …
Insights into amyotrophic lateral sclerosis linked Pro525Arg mutation in the fused in sarcoma protein through in silico analysis and molecular dynamics simulation
S Chatterjee, A Salimi, JY Lee - Journal of Biomolecular Structure …, 2021 - Taylor & Francis
A novel heterozygous mutation, Pro525Arg (P525R) in the Fused in Sarcoma (FUS) protein
is predominant in young adult females with familial amyotrophic lateral sclerosis (fALS) …
is predominant in young adult females with familial amyotrophic lateral sclerosis (fALS) …
Role of k-loop cysteine residues in the marburg virus protein VP24–human Keap1 complex
N Bhattarai, BS Gerstman, PP Chapagain - ACS Omega, 2018 - ACS Publications
Binding of the Marburg virus protein VP24 to the human Keap1 protein allows the nuclear
accumulation of Nrf2, activating cytoprotective antioxidant response pathways during the …
accumulation of Nrf2, activating cytoprotective antioxidant response pathways during the …