Oocyte activation deficiency: a role for an oocyte contribution?
BACKGROUND Infertility affects between 10 and 16% of couples worldwide. Twenty to 30%
of cases of infertility are due to a male factor, 20–35% to a female factor, and 25–40% are …
of cases of infertility are due to a male factor, 20–35% to a female factor, and 25–40% are …
Essential role of sperm-specific PLC-zeta in egg activation and male factor infertility: an update
Sperm-specific phospholipase C zeta (PLCζ) is widely considered to be the physiological
stimulus responsible for generating calcium (Ca2+) oscillations that induce egg activation …
stimulus responsible for generating calcium (Ca2+) oscillations that induce egg activation …
Sperm-borne phospholipase C zeta-1 ensures monospermic fertilization in mice
Sperm entry in mammalian oocytes triggers intracellular Ca2+ oscillations that initiate
resumption of the meiotic cell cycle and subsequent activations. Here, we show that …
resumption of the meiotic cell cycle and subsequent activations. Here, we show that …
A maternally inherited autosomal point mutation in human phospholipase C zeta (PLCζ) leads to male infertility
J Kashir, M Konstantinidis, C Jones… - Human …, 2012 - academic.oup.com
BACKGROUND Male factor and idiopathic infertility contribute significantly to global
infertility, with abnormal testicular gene expression considered to be a major cause. Certain …
infertility, with abnormal testicular gene expression considered to be a major cause. Certain …
Modulators of calcium signalling at fertilization
P Stein, V Savy, AM Williams… - Open biology, 2020 - royalsocietypublishing.org
Calcium (Ca2+) signals initiate egg activation across the animal kingdom and in at least
some plants. These signals are crucial for the success of development and, in the case of …
some plants. These signals are crucial for the success of development and, in the case of …
[HTML][HTML] Phospholipase Cζ rescues failed oocyte activation in a prototype of male factor infertility
M Nomikos, Y Yu, K Elgmati, M Theodoridou… - Fertility and sterility, 2013 - Elsevier
OBJECTIVE: To determine the effect of infertility-linked sperm phospholipase Cζ (PLCζ)
mutations on their ability to trigger oocyte Ca2+ oscillations and development, and also to …
mutations on their ability to trigger oocyte Ca2+ oscillations and development, and also to …
Sperm factors and egg activation: phospholipase C zeta (PLCZ1) and the clinical diagnosis of oocyte activation deficiency
C Jones, X Meng, K Coward - Reproduction, 2022 - rep.bioscientifica.com
Oocyte activation deficiency (OAD) remains the predominant cause of total/low fertilization
rate in assisted reproductive technology (ART). Phospholipase C zeta (PLCζ) is the …
rate in assisted reproductive technology (ART). Phospholipase C zeta (PLCζ) is the …
Egg activation at fertilization by a soluble sperm protein
K Swann, FA Lai - Physiological reviews, 2016 - journals.physiology.org
The most fundamental unresolved issue of fertilization is to define how the sperm activates
the egg to begin embryo development. Egg activation at fertilization in all species thus far …
the egg to begin embryo development. Egg activation at fertilization in all species thus far …
Loss of activity mutations in phospholipase C zeta (PLCζ) abolishes calcium oscillatory ability of human recombinant protein in mouse oocytes
BACKGROUND Mammalian oocyte activation occurs via a series of intracellular calcium
(Ca2+) oscillations thought to be induced by a sperm-specific phospholipase C zeta (PLCζ) …
(Ca2+) oscillations thought to be induced by a sperm-specific phospholipase C zeta (PLCζ) …
Recombinant human phospholipase C zeta 1 induces intracellular calcium oscillations and oocyte activation in mouse and human oocytes
BACKGROUND Oocyte activation is a crucial step that comprises the release of the oocyte
from meiotic arrest, pronuclear formation and subsequent embryo development. Oocytes are …
from meiotic arrest, pronuclear formation and subsequent embryo development. Oocytes are …