RNA-mediated regulation of HMGA1 function
AG Benecke, S Eilebrecht - Biomolecules, 2015 - mdpi.com
The high mobility group protein A1 (HMGA1) is a master regulator of chromatin structure
mediating its major gene regulatory activity by direct interactions with A/T-rich DNA …
mediating its major gene regulatory activity by direct interactions with A/T-rich DNA …
Exosomal delivery of 7SK long non-coding RNA suppresses viability, proliferation, aggressiveness and tumorigenicity in triple negative breast cancer cells
S Farhadi, S Mohammadi-Yeganeh, J Kiani… - Life Sciences, 2023 - Elsevier
Abstract Aims RN7SK (7SK), a highly conserved non-coding RNA, serves as a transcription
regulator via interaction with a few proteins. Despite increasing evidences which support the …
regulator via interaction with a few proteins. Despite increasing evidences which support the …
Anti-transcription factor RNA aptamers as potential therapeutics
E Mondragón, LJ Maher III - nucleic acid therapeutics, 2016 - liebertpub.com
Transcription factors (TFs) are DNA-binding proteins that play critical roles in regulating
gene expression. These proteins control all major cellular processes, including growth …
gene expression. These proteins control all major cellular processes, including growth …
CTIP2 is a negative regulator of P-TEFb
T Cherrier, V Le Douce, S Eilebrecht… - Proceedings of the …, 2013 - National Acad Sciences
The positive transcription elongation factor b (P-TEFb) is involved in physiological and
pathological events including inflammation, cancer, AIDS, and cardiac hypertrophy. The …
pathological events including inflammation, cancer, AIDS, and cardiac hypertrophy. The …
Structural basis for recognition of human 7SK long noncoding RNA by the La-related protein Larp7
CD Eichhorn, Y Yang, L Repeta… - Proceedings of the …, 2018 - National Acad Sciences
The La and the La-related protein (LARP) superfamily is a diverse class of RNA binding
proteins involved in RNA processing, folding, and function. Larp7 binds to the abundant long …
proteins involved in RNA processing, folding, and function. Larp7 binds to the abundant long …
HMGA1 recruits CTIP2-repressed P-TEFb to the HIV-1 and cellular target promoters
S Eilebrecht, V Le Douce, R Riclet, B Targat… - Nucleic acids …, 2014 - academic.oup.com
Active positive transcription elongation factor b (P-TEFb) is essential for cellular and human
immunodeficiency virus type 1 (HIV-1) transcription elongation. CTIP2 represses P-TEFb …
immunodeficiency virus type 1 (HIV-1) transcription elongation. CTIP2 represses P-TEFb …
The non-coding snRNA 7SKcontrols transcriptional termination, poising, and bidirectionality in embryonic stem cells
Background Pluripotency is characterized by a unique transcriptional state, in which lineage-
specification genes are poised for transcription upon exposure to appropriate stimuli, via a …
specification genes are poised for transcription upon exposure to appropriate stimuli, via a …
hLARP7 C-terminal domain contains an xRRM that binds the 3΄ hairpin of 7SK RNA
CD Eichhorn, R Chug, J Feigon - Nucleic acids research, 2016 - academic.oup.com
The 7SK small nuclear ribonucleoprotein (snRNP) sequesters and inactivates the positive
transcription elongation factor b (P-TEFb), an essential eukaryotic mRNA transcription factor …
transcription elongation factor b (P-TEFb), an essential eukaryotic mRNA transcription factor …
Transcription control by long non-coding RNAs
T Faust, A Frankel, I D'Orso - Transcription, 2012 - Taylor & Francis
Non-coding RNAs have been found to regulate many cellular processes and thus expand
the functional genetic repertoire contained within the genome. With the recent advent of …
the functional genetic repertoire contained within the genome. With the recent advent of …
The Bin3 RNA methyltransferase targets 7SK RNA to control transcription and translation
MS Cosgrove, Y Ding, WA Rennie… - Wiley …, 2012 - Wiley Online Library
Abstract Bicoid‐interacting protein 3 (Bin3) is a conserved RNA methyltransferase found in
eukaryotes ranging from fission yeast to humans. It was originally discovered as a Bicoid …
eukaryotes ranging from fission yeast to humans. It was originally discovered as a Bicoid …