Gene regulatory programmes of tissue regeneration

JA Goldman, KD Poss - Nature Reviews Genetics, 2020 - nature.com
Regeneration is the process by which organisms replace lost or damaged tissue, and
regenerative capacity can vary greatly among species, tissues and life stages. Tissue …

Long noncoding RNAs as emerging regulators of COVID-19

Q Yang, F Lin, Y Wang, M Zeng, M Luo - Frontiers in immunology, 2021 - frontiersin.org
Coronavirus disease 2019 (COVID-19), which has high incidence rates with rapid rate of
transmission, is a pandemic that spread across the world, resulting in more than 3,000,000 …

The emerging role of major regulatory RNAs in cancer control

X Dai, AC Kaushik, J Zhang - Frontiers in oncology, 2019 - frontiersin.org
Alterations and personal variations of RNA interactions have been mechanistically coupled
with disease etiology and phenotypical variations. RNA biomarkers, RNA mimics, and RNA …

A human ESC-based screen identifies a role for the translated lncRNA LINC00261 in pancreatic endocrine differentiation

B Gaertner, S Van Heesch, V Schneider-Lunitz… - Elife, 2020 - elifesciences.org
Long noncoding RNAs (lncRNAs) are a heterogenous group of RNAs, which can encode
small proteins. The extent to which developmentally regulated lncRNAs are translated and …

A high-resolution cell atlas of the domestic pig lung and an online platform for exploring lung single-cell data

L Zhang, J Zhu, H Wang, J Xia, P Liu, F Chen… - Journal of Genetics and …, 2021 - Elsevier
The genetically engineered pig is regarded as an optimal source of organ transplantation for
humans and an excellent model for human disease research, given its comparable …

PI3K signaling specifies proximal-distal fate by driving a developmental gene regulatory network in SOX9+ mouse lung progenitors

D Khattar, S Fernandes, J Snowball, M Guo, MC Gillen… - Elife, 2022 - elifesciences.org
The tips of the developing respiratory buds are home to important progenitor cells marked by
the expression of SOX9 and ID2. Early in embryonic development (prior to E13. 5), SOX9+ …

Comprehensive epigenomic profiling of human alveolar epithelial differentiation identifies key epigenetic states and transcription factor co-regulatory networks for …

B Zhou, TR Stueve, EA Mihalakakos, L Miao, D Mullen… - Bmc Genomics, 2021 - Springer
Background Disruption of alveolar epithelial cell (AEC) differentiation is implicated in distal
lung diseases such as chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis …

Muc5ac production inhibited by decreased lncRNA H19 via PI3K/Akt/NF-kB in asthma

X Chen, J Yang, H Shen, X Zhang, H Wang… - Journal of Asthma …, 2021 - Taylor & Francis
Introduction LncRNAs play important roles in multiple diseases including asthma, while
there are a few reports on the role of lncRNA H19 about asthma. This study aimed to …

LINC00261 is differentially expressed in pancreatic cancer subtypes and regulates a pro-epithelial cell identity

A Dorn, M Glass, CT Neu, B Heydel, S Huettelmaier… - Cancers, 2020 - mdpi.com
Pancreatic adenocarcinoma (PDAC) is one of the major causes of cancer-associated deaths
worldwide, with a dismal prognosis that has not significantly changed over the last decades …

Genome-wide differential expression profiling of long non-coding RNAs in FOXA2 knockout iPSC-derived pancreatic cells

AK Elsayed, NM Alajez, EM Abdelalim - Cell Communication and …, 2023 - Springer
Background Our recent studies have demonstrated the crucial involvement of FOXA2 in the
development of human pancreas. Reduction of FOXA2 expression during the differentiation …