Propolis is a honey-related product with reported health benefits such as improved
immunity, lowered blood pressure, treated allergies and skin conditions. A literature review …

The amino acid sequence of a protein affects both its structure and its function. Thus, the
ability to modify the sequence, and hence the structure and activity, of individual proteins in …

Abstract Pinocembrin (5, 7-dihydroxyflavone) is a major flavonoid found in many plants,
fungi and hive products, mainly honey and propolis. Several in vitro and preclinical studies …

Vascular cognitive impairment (VCI) describes a wide spectrum of cognitive deficits related
to cerebrovascular diseases. Although the loss of blood flow to cortical regions critically …

Flavanones are a group of flavonoids that derive from their immediate chalcone precursors
through the action of chalcone isomerase enzymes. The Aromatic A and B rings, C4‐keto …

Neuroinflammation is a major contributor to intracerebral hemorrhage (ICH) progression, but
no drug is currently available to reduce this response and protect against ICH-induced …

Stroke is one of the main causes of mortality and disability, and it is due to be included in
monetary implications on wellbeing frameworks around the world. Ischemic stroke is caused …

Background: Nod-like receptor protein 3 (NLRP3) inflammasome is a crucial contributor in
the inflammatory process during cerebral ischemia/reperfusion (I/R) injury. ATF4 plays a …

Background: Recent reports suggested the involvement of oxidative stress-and endoplasmic
reticulum stress (ERS)-associated pathways in the progression of ischemia/reperfusion (I/R) …

Pinocembrin is a natural flavonoid compound extracted from honey, propolis, ginger roots,
wild marjoram, and other plants. In preclinical studies, it has shown anti-inflammatory and …