Kidney considerations in pediatric obesity

A Sawyer, E Zeitler, H Trachtman, P Bjornstad - Current Obesity Reports, 2023 - Springer
Abstract Purpose of Review Chronic kidney disease (CKD) is a common condition and a
major cause of morbidity and mortality in adults, but children and adolescents are also at risk …

Chronic treatment with IL-25 increases renal M2 macrophages and reduces renal injury in obese Dahl salt-sensitive rats during the prepubescent stage

B Poudel, US Ekperikpe, S Mandal… - American Journal …, 2023 - journals.physiology.org
Recently, we have reported that the early progression of proteinuria in the obese Dahl salt-
sensitive (SS) leptin receptor mutant (SSLepRmutant) strain was associated with increased …

Neutralizing MIP3α Reduces Renal Immune Cell Infiltration and Progressive Renal Injury in Young Obese Dahl Salt-Sensitive Rats

US Ekperikpe, B Poudel, CA Shields, S Mandal… - … of Pharmacology and …, 2023 - ASPET
Recently, we reported that the early progression of renal injury in obese Dahl salt-sensitive
leptin receptor mutant (SSLepRmutant) rats was associated with increased macrophage …

Metformin reduces insulin resistance and attenuates progressive renal injury in prepubertal obese Dahl salt-sensitive rats

US Ekperikpe, S Mandal, SJ Holt… - American Journal …, 2023 - journals.physiology.org
Prepubertal obesity is currently an epidemic and is considered as a major risk factor for
renal injury. Previous studies have demonstrated that insulin resistance contributes to renal …

L-arginine and lisinopril supplementation protects against sodium fluoride–induced nephrotoxicity and hypertension by suppressing mineralocorticoid receptor and …

TO Ajibade, OA Awodele, MO Tijani… - … Science and Pollution …, 2023 - Springer
Sodium fluoride (NaF) is one of the neglected environmental toxicants that has continued to
silently cause toxicity to both humans and animals. NaF is universally present in water, soil …

[HTML][HTML] Nephroprotective effects of diminazene on doxorubicin-induced acute kidney injury in rats

Y Al Suleimani, R Al Maskari, BH Ali, H Ali, P Manoj… - Toxicology Reports, 2023 - Elsevier
This study aimed to investigate the potential protective effects of diminazene, an activator of
angiotensin II converting enzyme (ACE2), on kidney function and structure in rats with acute …

Frontiers in metabolic physiology grand challenges

JD Imig - Frontiers in Physiology, 2022 - frontiersin.org
Metabolic physiology is defined as the molecular, cellular, organ, and organism biological
processes that provide energy to maintain homeostasis. Research on metabolism touches …

Abatacept decreases renal T-cell infiltration and renal inflammation and ameliorates progressive renal injury in obese Dahl salt-sensitive rats before puberty

US Ekperikpe, S Mandal, AA Bhopatkar… - Journal of …, 2022 - journals.lww.com
Prepubertal obesity (PPO) is growing at an alarming rate and is now considered a risk factor
for renal injury. Recently, we reported that the early development of renal injury in obese …