Duchenne muscular dystrophy (DMD) is caused by frameshift mutations in the DMD gene
that prevent the body-wide translation of its protein product, dystrophin. Besides a severe …

Dystrophin is the central protein of the dystrophin-glycoprotein complex (DGC) in skeletal
and heart muscle cells. Dystrophin connects the actin cytoskeleton to the extracellular matrix …

Dystrophin Dp71 is expressed in all tissues, with the exception of skeletal muscle, and is the
main Duchenne muscular dystrophy (DMD) gene product in brain. As full-length dystrophin …

Two decades of molecular, cellular, and functional studies considerably increased our
understanding of dystrophins function and unveiled the complex etiology of the cognitive …

Pretranslational modification by alternative splicing, alternative promoter usage and RNA
editing enables the production of multiple protein isoforms from a single gene. A large …

Dystrophin-glycoprotein complex (DGC) is an important structural unit in skeletal muscle that
connects the cytoskeleton (f-actin) of a muscle fiber to the extracellular matrix (ECM) …

We recently characterized a nuclear import pathway for β-dystroglycan; however, its nuclear
role remains unknown. In this study, we demonstrate for the first time, the interaction of β …

Background: Dp71 is the most abundant dystrophin (DMD) gene product in the nervous
system. Mutation in the Dp71 coding region is associated with cognitive disturbances in …

The function of dystrophin Dp71 in neuronal cells remains to be established. Previously, we
revealed the involvement of this protein in both nerve growth factor (NGF)-induced neuronal …

Alterations in Dp71 expression, the most ubiquitous dystrophin isoform, have been
associated with patient survival across tumours. Intriguingly, in certain malignancies, Dp71 …