When faced with increased workload the heart undergoes remodelling, where it increases
its muscle mass in an attempt to preserve normal function. This is referred to as cardiac …

Mitochondria, which serve as the energy factories of cells, are involved in cell differentiation,
calcium homeostasis, amino acid and fatty acid metabolism and apoptosis. In response to …

Physiological reactive oxygen species (ROS) are important regulators of intercellular signal
transduction. Oxidative and antioxidation systems maintain a dynamic balance under …

Abstract Background Mitochondria-derived peptides (MDPs) represent a recently discovered
family of peptides encoded by short open reading frames (ORFs) found within mitochondrial …

Infection by the protozoan Trypanosoma cruzi causes Chagas disease cardiomyopathy
(CCC) and can lead to arrhythmia, heart failure and death. Chagas disease affects 8 million …

Polycystic ovary syndrome (PCOS) is the most common endocrinological pathology among
women of reproductive age, whereas the pathogenesis is still not fully understood. Systemic …

With technological advances, previously neglected noncanonical open reading frames
(nORFs) are drawing ever-increasing attention. However, the translation potential of …

Abstract The sirtuin 6 (SIRT6) participates in regulating glucose and lipid homeostasis.
However, the function of SIRT6 in the process of cardiac pathogenesis caused by obesity …

Pathological remodeling is the main detrimental complication after myocardial infarction
(MI). Overproduction of reactive oxygen species (ROS) in infarcted myocardium may …

Background: Doxorubicin (DOX) is a potent chemotherapeutic agent with limited usage due
to its cumulative cardiotoxicity. The Na+/H+ exchanger isoform 1 (NHE1) is a known …