The renin-angiotensin system (RAS) is a key player in the control of the cardiovascular
system and hydroelectrolyte balance, with an influence on organs and functions throughout …

Obesity is a global epidemic representing a serious public health burden as it is a major risk
factor for the development of cardiovascular disease, stroke and all-cause mortality. Chronic …

It is well known that the RAS (renin–angiotensin system) plays a key role in the modulation
of many functions in the body. AngII (angiotensin II) acting on AT1R (type 1 AngII receptor) …

The current outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2), termed coronavirus disease 2019 (COVID-19), has generated a notable challenge …

Abstract Angiotensin converting enzyme-2 (ACE2) is a multifunctional transmembrane
protein recently recognised as the entry receptor of the virus causing COVID-19. In the renin …

The Mas-related G protein–coupled receptors (Mrgprs or Mas-related genes) comprise a
subfamily of receptors named after the first discovered member, Mas. For most Mrgprs …

Skeletal muscle is a tissue that shows the most plasticity in the body; it can change in
response to physiological and pathological stimuli. Among the diseases that affect skeletal …

Obesity is an independent risk factor for the development and progression of chronic kidney
disease and one of the emerging reasons for end-stage renal disease owing to its dramatic …

Aims The renin-angiotensin system (RAS) is a dual system with two opposite arms: i) the
classical one formed by the angiotensin converting enzyme (ACE), angiotensin (Ang) II and …

Overactivation of the renin–angiotensin (Ang) system (RAS) increases the classical arm
(Ang-converting enzyme (ACE)/Ang II/Ang type 1 receptor (AT1R)) to the detriment of the …