The immune system deploys a multitude of innate and adaptive mechanisms not only to
ward off pathogens but also to prevent malignant transformation (“immune surveillance”) …

HLA-G is a molecule that was first known to confer protection to the fetus from destruction by
the immune system of its mother, thus critically contributing to fetal–maternal tolerance. The …

Immune cells, as a consequence of their plasticity, can acquire altered phenotype/functions
within the tumor microenvironment (TME). Some of these aberrant functions include …

Human leukocyte antigen G (HLA-G), known as a central protein in providing immune
tolerance to the fetus in pregnant women, is also studied for a possible role in tumor …

Aberrant induction of human leukocyte antigen-G (HLA-G) expression has been observed in
various malignancies and is strongly associated with tumor immune escape, metastasis and …

Abstract Background The Human Leukocyte Antigen G (HLA-G) protein is an immune
tolerogenic molecule with 7 isoforms. The change of expression level and some …

The expression of classical human leukocyte antigen class I antigens (HLA‐I) on the
surfaces of cancer cells allows cytotoxic T cells to recognize and eliminate these cells …

Background Tumors avoid destruction by cytotoxic T cells (CTL) and natural killer (NK) cells
by downregulation of classical human leukocyte antigens (HLA) and overexpression of non …

As a non-classic major histocompatibility complex (MHC) class I molecule, human leukocyte
antigen G (HLA-G) is expressed in fetal-maternal interface and immunoprivileged site only in …

Human leukocyte antigen-G (HLA-G) conveys immunological tolerance at the maternal-
foetal interface. HLA-G expression by tumour cells may also play such a role, resulting in …