Drug-loaded hyaluronic acid hydrogel as a sustained-release regimen with dual effects in early intervention of tendinopathy

MY Hsiao, AC Lin, WH Liao, TG Wang, CH Hsu… - Scientific Reports, 2019 - nature.com
Resulting from accumulative microtrauma, impaired healing and oxidative stress,
tendinopathy is a debilitating and relentlessly deteriorating disease that greatly affects daily …

[HTML][HTML] Continuous release of mefloquine featured in electrospun fiber membranes alleviates epidural fibrosis and aids in sensory neurological function after lumbar …

Z Yue, B Hu, Z Chen, G Zheng, Y Wang, C Yang… - Materials Today Bio, 2022 - Elsevier
Recurrent low back pain after spinal surgeries, such as lumbar laminectomy, is a major
complication of excessive epidural fibrosis. Although multiple preclinical and clinical …

Using cross-linked hyaluronic acid gel to prevent postoperative lumbar epidural space adhesion: in vitro and in vivo studies

K Wang, X Li, J Liu, X Sun, H Yang, X Gao - European Spine Journal, 2020 - Springer
Purpose Hyaluronic acid prevents tissue adhesion after different surgeries. Physical barriers
and inflammatory regulation have been suggested to be involved in the mechanism of these …

Anti-adhesive effect of poloxamer-based thermo-sensitive sol-gel in rabbit laminectomy model

SJ Shin, JH Lee, J So, K Min - Journal of Materials Science: Materials in …, 2016 - Springer
Poloxamer-based thermo-sensitive sol-gel has been developed to reduce the incidence of
postoperative scar formation at the laminectomy site. The purpose of this study was to …

[PDF][PDF] In situ forming oxidised hyaluronic acid/adipic acid dihydrazide hydrogel for prevention of epidural fibrosis after laminectomy

MH Hu, KC Yang, YH Sun, YC Chen, SH Yang… - Eur Cell …, 2017 - ecmjournal.org
Post-operative epidural fibrosis is a biological response after laminectomy that may lead to
clinical symptoms, such as radicular pain. An ideal material for prevention of epidural …

The role of pharmacological agents in nerve regeneration after peripheral nerve repair

A Mekaj, Y Mekaj - Peripher. Nerve Regen. Surg. New Ther …, 2017 - books.google.com
Peripheral nerve injuries are frequent and represent a significant pathology of the peripheral
nervous system because, despite operative techniques and successful microsurgical repair …

Experimental model of intervertebral disk mediated postoperative epidural fibrosis

SN Larionov, VA Sorokovikov, KC Erdyneyev… - Annals of …, 2016 - karger.com
Background: Postoperative epidural fibrosis (EF) after lumbar discectomy is the most
common and at the same time controversial issue. Purpose: The etiology and pathogenesis …

Prospective application of stem cells to prevent post‐operative skeletal fibrosis

X Li, S Chen, L Yan, J Wang… - Journal of Orthopaedic …, 2019 - Wiley Online Library
Post‐operative skeletal fibrosis is considered one of the major complications causing
dysfunction of the skeletal system and compromising the outcomes of clinical treatment …

[PDF][PDF] Intervertebral disk mediated postoperative epidural fibrosis: experimental model and methods of prevention

SN Larionov, VA Sorokovikov, KC Erdyneyev… - Clin Surg. 2017 …, 2017 - clinicsinsurgery.com
The etiology and pathogenesis creates a lot of discussion, and selection of methods of
treatment and prevention continues. In this study we used 36 male Wistar rats, each …

[PDF][PDF] Prevention of failed back surgery syndrome with applications of different pharmacological agents: A review article

Y Mekaj, A Mekaj - Ther Targets Neurol Dis, 2015 - researchgate.net
Failed back surgery syndrome (FBSS) is a severe, long lasting and very common
complication of lumbosacral spine surgery. FBSS can result from a variety of factors, such as …