Autophagy and RNA alternative splicing are two evolutionarily conserved processes
involved in overlapping physiological and pathological processes. However, the extent of …

Dysregulation of messenger RNA (mRNA) processing—in particular mRNA splicing—is a
hallmark of cancer. Compared to normal cells, cancer cells frequently present aberrant …

Background The poor prognosis and rising incidence of esophageal adenocarcinoma
highlight the need for improved detection methods. The potential for circulating microRNAs …

Ovarian cancer ascites is a native medium for cancer cells that allows investigation of their
secretome in a natural environment. This medium is of interest as a promising source of …

The spliceosome machinery is composed of multimeric protein complexes that generate a
diverse repertoire of mRNA through coordinated splicing of heteronuclear RNAs. While …

Background and Purpose: Breast cancer is one of the leading causes of death among
women. RNA binding proteins (RBPs) play a vital role in the progression of many cancers …

Hepatocellular carcinoma (HCC) is among the commonest kind of malignant tumors, which
accounts for more than 500,000 cases of newly diagnosed cancer annually. Many …

Over 80% of multiple-tested siRNAs and shRNAs targeting CD95 or CD95 ligand (CD95L)
induce a form of cell death characterized by simultaneous activation of multiple cell death …

SNRPB is a core component of spliceosome and plays a major role in regulating alternative
splicing of the pre-mRNA. However, little is known about its role in cancer to date. In this …

Here we describe isolation and characterization of macrophage-tumor cell fusions (MTFs)
from the blood of pancreatic ductal adenocarcinoma (PDAC) patients. The MTFs were …