In vitro liver cell culture models are gaining increasing importance in pharmacological and
toxicological research. The source of cells used is critical for the relevance and the …

Abstract Knowledge of the metabolic stability of a new drug substance eliminated by
biotransformation is essential for envisaging the pharmacokinetic parameters required for …

Recent technological advances in the generation, characterization, and bioprocessing of
human pluripotent stem cells (hPSCs) have created new hope for their use as a source for …

Early consideration of the multiplicity of factors that govern the biological fate of foreign
compounds in living systems is a necessary prerequisite for the quantitative in vitro–in vivo …

Background aims Human umbilical cord (UC) has become a notable source for
mesenchymal stromal cells (MSCs) that can migrate to areas of inflammation and damaged …

Mesenchymal stem cells (MSCs) have vast potential in cell therapy, and are experimentally
used in the clinic. Therefore, it is critical to find a serum-and xeno-free cryopreservation …

Background Amnion-derived stem cells have been proposed for cell replacement therapy
and tissue regeneration. An easily accessible cell source, the placenta, allows us to …

Bioengineered dermal substitutes have been used for the treatment of diabetic ulcers in
clinics and achieved satisfactory results. However, constructing traditional tissue engineered …

Hepatocyte transplantation is a promising treatment for liver failure and inborn metabolic
liver diseases, but progress has been hampered by a scarcity of available organs. Here …

Clinical applications of gamma delta (γδ) T cells have advanced from initial interest in
expanding γδ T cells in vivo to the development of a manufacturing process for the ex vivo …