The pathophysiology of epilepsy has been historically grounded on hyperexcitability
attributed to the oversimplified imbalance between excitation (E) and inhibition (I) in the …

The ability of neurons to communicate and store information depends on the activity of
synapses which can be located on small protrusions (dendritic spines) or directly on the …

Mutations disrupting the nuclear localization of the RNA-binding protein FUS characterize a
subset of amyotrophic lateral sclerosis patients (ALS-FUS). FUS regulates nuclear RNAs …

Neurons express various combinations of neurotransmitter receptor (NR) subunits and
receive inputs from multiple neuron types expressing different neurotransmitters. Localizing …

Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) is the most common
focal epilepsy in adults. It is characterized by alarming rates of pharmacoresistance …

Muscle dystrophin–glycoprotein complex (DGC) links the intracellular cytoskeleton to the
extracellular matrix. In neurons, dystroglycan and dystrophin, two major components of the …

Developmental and epileptic encephalopathies (DEE) are rare but devastating and largely
intractable childhood epilepsies. Genetic variants in ARHGEF9, encoding a scaffolding …

Intellectual disability (ID) is a common neurodevelopmental disorder that can arise from
genetic mutations ranging from trisomy to single nucleotide polymorphism. Mutations in a …

Recent advances in 3d electron microscopy are yielding ever larger reconstructions of brain
tissue, encompassing thousands of individual neurons interconnected by millions of …

We are studying the mechanisms of H‐reflex operant conditioning, a simple form of learning.
Modelling studies in the literature and our previous data suggested that changes in the axon …