Pharmaceutical research has successfully incorporated a wealth of molecular modeling
methods, within a variety of drug discovery programs, to study complex biological and …

Inflammation plays a crucial role in the development of many complex diseases and
disorders including autoimmune diseases, metabolic syndrome, neurodegenerative …

Discovering the unintended 'off-targets' that predict adverse drug reactions is daunting by
empirical methods alone. Drugs can act on several protein targets, some of which can be …

Searching for effective and selective anti‐inflammatory agents, our study involved designing
and synthesizing new pyrazole and pyrazolo [1, 5‐a] pyrimidine derivatives 4–11. The …

Coumarins are natural products characterized as 1, 2 benzopyrones widely distributed in
plants, as well as, in many species of fungi and bacteria. Nowadays, many synthetic …

Two major challenges facing cancer immunotherapy are the relatively low therapeutic
efficacy and the potential side effects. New drug delivery system and efficient drug …

Simple Summary Inflammation is like the proverbial double-edged sword. Controlled short-
term inflammation could be a protective response while uncontrolled inflammation sustains …

Inflammation is a hallmark of many diseases, including cancer, neurodegenerative diseases
like Alzheimer's, type II diabetes, rheumatoid arthritis, and asthma. Nonsteroidal anti …

Introduction Mesenchymal stem cells can potentially be used in therapy for spinal cord injury
(SCI). Methylprednisolone sodium succinate (MPSS) has been used as a scavenging agent …

Abstract Treatment of pain has always been a major goal in the clinic, as it is related to
several pathological conditions of inflammatory origin and surgical procedures, which are …