Trabectedin (TRB) and Lurbinectedin (LUR) are alkaloid compounds originally isolated from
Ecteinascidia turbinata with proven antitumoral activity. Both molecules are structural …

Background and objectives Non-small cell lung cancer (NSCLC) is a global health concern.
NSCLC treatment outcomes are generally poor due to treatment resistance or toxicity …

In recent years, the central role of cell bioenergetics in regulating immune cell function and
fate has been recognized, giving rise to the interest in immunometabolism, an area of …

The bioavailability and regulation of iron is essential for central biological functions in
mammals. The role of this element in ferroptosis and the dysregulation of its metabolism …

Experimental evidence indicates that the control of the inflammatory response after
myocardial infarction is a key strategy to reduce cardiac injury. Cellular damage after blood …

A considerable proportion of cancer patients are resistant or only partially responsive to
immune checkpoint blockade immunotherapy. Tumor‐Associated Macrophages (TAMs) …

Studying the tumor microenvironment and surrounding lymph nodes is the main focus of
current immunological research on soft tissue sarcomas (STS). However, due to the …

Simple Summary Bladder cancer (BC) is the second most frequent cancer of the
genitourinary system. More than 500,000 patients per year are diagnosed with BC, a …

Immune cells have an important role in the tumor-microenvironment. Macrophages may tune
the immune response toward inflammatory or tolerance pathways. Tumor-associated …

The interaction of two types of fragmented graphene particles (30–160 nm) with human
macrophages is studied. Since macrophages have significant phagocytic activity, the …