Myofibrillar myopathies (MFMs) represent a group of muscular dystrophies with a similar
morphological phenotype. The diagnosis is established by muscle biopsy. The MFMs are …

Cardiac disease is a common clinical manifestation of neuromuscular disorders, particularly
of muscular dystrophies. Heart muscle cells as well as specialized conducting myocardial …

Background and Objective: The term myofibrillar myopathy (MFM) is a noncommittal term for
a pathologic pattern of myofibrillar dissolution associated with accumulation of myofibrillar …

Objective: To compare muscle imaging findings in different subtypes of myofibrillar
myopathies (MFM) in order to identify characteristic patterns of muscle alterations that may …

Myofibrillar myopathy (MFM) is a morphologically distinct disorder in which disintegration of
the Z‐disk and then of the myofibrils is followed by abnormal accumulation of multiple …

The Z-disc acts as a protein-rich structure to tether thin filament in the contractile units, the
sarcomeres, of striated muscle cells. Proteins found in the Z-disc are integral for maintaining …

Over sixty years ago John Walton and Frederick Nattrass defined limb girdle muscular
dystrophy (LGMD) as a separate entity from the X-linked dystrophinopathies such as …

The assembly and maintenance of the muscle sarcomere requires a complex interplay of
actin-and myosin-associated proteins. Myotilin is a thin filament-associated Z-disc protein …

The limb‐girdle muscular dystrophies are a diverse group of muscle‐wasting disorders
characteristically affecting the large muscles of the pelvic and shoulder girdles. Molecular …

The muscular dystrophies are a heterogeneous group of disorders defined by dystrophic
pathologic features on muscle biopsy. Clinically, they are characterized by progressive …