Eukaryotic cells have divided the steps of gene expression between their nucleus and
cytoplasm. Protein-encoding genes generate mRNAs in the nucleus and mRNAs undergo …

Motivation Protein–RNA interactions play a critical role in various biological processes. The
accurate prediction of RNA-binding residues in proteins has been one of the most …

The recognition of the 5′ splice site (5′ ss) is one of the earliest steps of pre-mRNA
splicing. To better understand, the mechanism and regulation of 5′ ss recognition, we …

Opioid receptors, a kind of G protein-coupled receptors (GPCRs), mainly mediate an
analgesic response via allosterically transducing the signal of endogenous ligand binding in …

Understanding generic mechanisms of functions shared by the secretory phospholipase A2
(sPLA2) family involved in the lipid metabolism and cell signaling and the molecular basis of …

Polypyrimidine tract-binding protein (PTB), an RNA-binding protein, is involved in the
regulation of diverse processes in mRNA metabolism. However, the allosteric modulation of …

Dynamical properties of proteins play an essential role in their function exertion. The elastic
network model (ENM) is an effective and efficient tool in characterizing the intrinsic …

The inwardly rectifying potassium channel Kir3. 2, a member of the inward rectifier
potassium (Kir) channel family, exerts important biological functions through transporting …

Human multidrug resistance protein 1 (hMRP1) is an important member of the ATP‐binding
cassette (ABC) transporter superfamily. It can extrude a variety of anticancer drugs and …

We investigated the capability of internal normal modes to reproduce RNA flexibility and
predict observed RNA conformational changes and, notably, those induced by the formation …