Lipid metabolism and cancer
Dysregulation in lipid metabolism is among the most prominent metabolic alterations in
cancer. Cancer cells harness lipid metabolism to obtain energy, components for biological …
cancer. Cancer cells harness lipid metabolism to obtain energy, components for biological …
Homeostasis of glucose and lipid in non-alcoholic fatty liver disease
Industrialized society-caused dysregular human behaviors and activities such as
overworking, excessive dietary intake, and sleep deprivation lead to perturbations in the …
overworking, excessive dietary intake, and sleep deprivation lead to perturbations in the …
Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c
Mammalian target of rapamycin complex 2 (mTORC2) phosphorylates and activates AGC
kinase family members, including Akt, SGK1, and PKC, in response to insulin/IGF1. The liver …
kinase family members, including Akt, SGK1, and PKC, in response to insulin/IGF1. The liver …
[HTML][HTML] Selective inhibition of FOXO1 activator/repressor balance modulates hepatic glucose handling
Insulin resistance is a hallmark of diabetes and an unmet clinical need. Insulin inhibits
hepatic glucose production and promotes lipogenesis by suppressing FOXO1-dependent …
hepatic glucose production and promotes lipogenesis by suppressing FOXO1-dependent …
Peroxisome proliferation–associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity
Previous studies have proposed roles for hypothalamic reactive oxygen species (ROS) in
the modulation of circuit activity of the melanocortin system,. Here we show that suppression …
the modulation of circuit activity of the melanocortin system,. Here we show that suppression …
Broad anti-tumor activity of a small molecule that selectively targets the Warburg effect and lipogenesis
Malignant cells exhibit aerobic glycolysis (the Warburg effect) and become dependent on de
novo lipogenesis, which sustains rapid proliferation and resistance to cellular stress. The …
novo lipogenesis, which sustains rapid proliferation and resistance to cellular stress. The …
[HTML][HTML] Role of nuclear receptor SHP in metabolism and cancer
Y Zhang, CH Hagedorn, L Wang - … Acta (BBA)-Molecular Basis of Disease, 2011 - Elsevier
Small heterodimer partner (SHP, NR0B2) is a unique member of the nuclear receptor (NR)
superfamily that contains the dimerization and ligand-binding domain found in other family …
superfamily that contains the dimerization and ligand-binding domain found in other family …
[HTML][HTML] Farnesoid X receptor: A “homeostat” for hepatic nutrient metabolism
V Massafra, SWC van Mil - Biochimica et Biophysica Acta (BBA)-Molecular …, 2018 - Elsevier
Abstract The Farnesoid X receptor (FXR) is a nuclear receptor activated by bile acids (BAs).
BAs are amphipathic molecules that serve as fat solubilizers in the intestine under …
BAs are amphipathic molecules that serve as fat solubilizers in the intestine under …
Liver glucokinase: An overview on the regulatorymechanisms of its activity
Blood glucose is the primary cellular substrate and in vivo must be tightly maintained. The
liver plays a key role in glucose homeostasis increasing or decreasing glucose output and …
liver plays a key role in glucose homeostasis increasing or decreasing glucose output and …
Enhanced expression of pro-inflammatory mediators and liver X-receptor-regulated lipogenic genes in non-alcoholic fatty liver disease and hepatitis C
E Lima-Cabello, MV Garcia-Mediavilla… - Clinical …, 2011 - portlandpress.com
NAFLD (non-alcoholic fatty liver disease) is one of the most frequent chronic liver diseases
worldwide. The metabolic factors associated with NAFLD are also determinants of liver …
worldwide. The metabolic factors associated with NAFLD are also determinants of liver …