Liquid biopsies come of age: towards implementation of circulating tumour DNA
Improvements in genomic and molecular methods are expanding the range of potential
applications for circulating tumour DNA (ctDNA), both in a research setting and as a'liquid …
applications for circulating tumour DNA (ctDNA), both in a research setting and as a'liquid …
PCR-based methods for the enrichment of minority alleles and mutations
CA Milbury, J Li, GM Makrigiorgos - Clinical chemistry, 2009 - academic.oup.com
Background: The ability to identify low-level somatic DNA mutations and minority alleles
within an excess wild-type sample is becoming essential for characterizing early and …
within an excess wild-type sample is becoming essential for characterizing early and …
Detection of free‐circulating tumor‐associated DNA in plasma of colorectal cancer patients and its association with prognosis
T Lecomte, A Berger, F Zinzindohoué… - … journal of cancer, 2002 - Wiley Online Library
Tumor cells are characterized by specific genetic alterations. When such genetic alterations
are identified in body fluid including plasma, regardless of the presence of detectable tumor …
are identified in body fluid including plasma, regardless of the presence of detectable tumor …
Inactivation of the DNA Repair Gene O6-Methylguanine-DNA Methyltransferase by Promoter Hypermethylation Is Associated with G to A Mutations in K-ras in …
Abstract O 6-Methylguanine DNA methyltransferase (MGMT) is a DNA repair protein that
removes mutagenic and cytotoxic adducts from the O 6 position of guanine. O 6 …
removes mutagenic and cytotoxic adducts from the O 6 position of guanine. O 6 …
Genetic and histological assessment of surgical margins in resected liver metastases from colorectal carcinoma: minimum surgical margins for successful resection
N Kokudo, Y Miki, S Sugai, A Yanagisawa… - Archives of …, 2002 - jamanetwork.com
Hypothesis There have been few reports on the minimum surgical margins (SMs) required
for successful liver resection in patients with colorectal metastases. This minimum …
for successful liver resection in patients with colorectal metastases. This minimum …
Bioinformatically detectable group of novel regulatory genes and uses thereof
I Bentwich - US Patent 7,250,496, 2007 - Google Patents
The present invention relates to a first group of novel genes, here identified as “genomic
address messenger” or “GAM” genes, and a second group of novel operon-like genes, here …
address messenger” or “GAM” genes, and a second group of novel operon-like genes, here …
[HTML][HTML] Analytical validation of a next generation sequencing liquid biopsy assay for high sensitivity broad molecular profiling
V Plagnol, S Woodhouse, K Howarth, S Lensing… - PloS one, 2018 - journals.plos.org
Circulating tumor DNA (ctDNA) analysis is being incorporated into cancer care; notably in
profiling patients to guide treatment decisions. Responses to targeted therapies have been …
profiling patients to guide treatment decisions. Responses to targeted therapies have been …
Methods for the detection of loss of heterozygosity
SN Lapidus, AP Shuber - US Patent 5,928,870, 1999 - Google Patents
This invention relates to methods useful for disease diagnosis by detecting loss of
heterozygosity in cellular samples containing a small amount of mutated genetic material …
heterozygosity in cellular samples containing a small amount of mutated genetic material …
Detection of K-ras gene mutations in plasma DNA of patients with pancreatic adenocarcinoma: correlation with clinicopathological features.
T Yamada, S Nakamori, H Ohzato, S Oshima… - Clinical cancer research …, 1998 - AACR
We investigated the presence of K-ras gene mutation in plasma DNA and assessed its
clinical value in patients with pancreatic adenocarcinoma. Mutations in codon 12 of the K …
clinical value in patients with pancreatic adenocarcinoma. Mutations in codon 12 of the K …
Method for the detection of clonal populations of transformed cells in a genomically heterogeneous cellular sample
SN Lapidus, AP Shuber, KM Ulmer - US Patent 5,670,325, 1997 - Google Patents
54 METHOD FOR THE DETECTION OF FOREIGN PATENT DOCUMENTS CLONAL
POPULATIONS OF A-11325/95 10/1994 Australia. TRANSFORMED CELLS INA 0284362 …
POPULATIONS OF A-11325/95 10/1994 Australia. TRANSFORMED CELLS INA 0284362 …