Biosynthesis of peptide hormones by pancreatic islet endocrine cells is a tightly orchestrated
process that is critical for metabolic homeostasis. Like neuroendocrine peptides, insulin and …

Carboxypeptidase E (CPE) or carboxypeptidase H was first discovered in 1982 as an
enkephalin-convertase that cleaved a C-terminal basic residue from enkephalin precursors …

Alzheimer's Disease (AD) is a prevalent neurodegenerative disease characterized by tau
hyperphosphorylation, Aβ1-42 aggregation and cognitive dysfunction. Therapeutic agents …

Background Ideally, disease modifying therapies for Alzheimer disease (AD) will be applied
during the 'preclinical'stage (pathology present with cognition intact) before severe neuronal …

Reduced food intake brings about an adaptive decrease in energy expenditure that
contributes to the recidivism of obesity after weight loss. Insulin and leptin inhibit food intake …

Carboxypeptidase E is a peptide processing enzyme, involved in cleaving numerous
peptide precursors, including neuropeptides and hormones involved in appetite control and …

Protecting neurons from death during oxidative and neuroexcitotoxic stress is key for
preventing cognitive dysfunction. We uncovered a novel neuroprotective mechanism …

Since discovery in 1982, carboxypeptidase E (CPE) has been shown to be involved in the
biosynthesis of a wide range of neuropeptides and peptide hormones in endocrine tissues …

Major depressive disorder is often linked to stress. Although short-term stress is without
effect in mice, prolonged stress leads to depressive-like behavior, indicating that an …

Introduction Cattle temperament is an important factor that affects the profitability of beef
cattle enterprises, due to its relationship with productivity traits, animal welfare and labor …