The evolution of antibiotic-resistant bacteria is an ongoing and troubling development that
has increased the number of diseases and infections that risk going untreated. There is an …

The global increase in antimicrobial drug resistance has dramatically reduced the
effectiveness of traditional antibiotics. Structurally diverse antibiotics are urgently needed to …

Small-angle x-ray solution scattering (SAXS) is analyzed with a new method to retrieve
convergent model structures that fit the scattering profiles. An arbitrary hexagonal packing of …

Genetic and Evolutionary Algorithms Page 1 CGA04- Genetic and Evolutionary Algorithms
Gareth Jones University of Sheffield, UK 1 Introduction 2 Evolutionary Algorithms 3 Applications …

If protein structure prediction methods are to make any impact on the impending onerous
task of analyzing the large numbers of unknown protein sequences generated by the …

In recent years, search and optimisation algorithms inspired by evolutionary processes have
been applied with marked success to a wide variety of problems in diverse fields of study. In …

CODA, an algorithm for predicting the variable regions in proteins, combines FREAD a
knowledge based approach, and PETRA, which constructs the region ab initio. FREAD …

Genetic algorithms are a general class of search methods that mimic natural gene-based
optimization mechanisms. Mutation, cross-over and replication operations are performed on …

The capabilities of current protein structure prediction methods have been assessed from
the outcome of a set of blind tests. In comparative modeling, many of the numerical methods …

We have explored the application of genetic algorithms (GA) to the determination of protein
structure from sequence, using a full atom representation. A free energy function with point …