Ribosome biogenesis factors—from names to functions

K Dörner, C Ruggeri, I Zemp, U Kutay - The EMBO journal, 2023 - embopress.org
The assembly of ribosomal subunits is a highly orchestrated process that involves a huge
cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified …

Ribosome assembly coming into focus

S Klinge, JL Woolford Jr - Nature reviews Molecular cell biology, 2019 - nature.com
In the past 25 years, genetic and biochemical analyses of ribosome assembly in yeast have
identified most of the factors that participate in this complex pathway and have generated …

Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis

RY Ebright, S Lee, BS Wittner, KL Niederhoffer… - Science, 2020 - science.org
Circulating tumor cells (CTCs) are shed into the bloodstream from primary tumors, but only a
small subset of these cells generates metastases. We conducted an in vivo genome-wide …

Local and global influences on protein turnover in neurons and glia

AR Dörrbaum, L Kochen, JD Langer, EM Schuman - Elife, 2018 - elifesciences.org
Regulation of protein turnover allows cells to react to their environment and maintain
homeostasis. Proteins can show different turnover rates in different tissue, but little is known …

The Syntrophy hypothesis for the origin of eukaryotes revisited

P López-García, D Moreira - Nature microbiology, 2020 - nature.com
The discovery of Asgard archaea, phylogenetically closer to eukaryotes than other archaea,
together with improved knowledge of microbial ecology, impose new constraints on …

Messenger RNA transport on lysosomal vesicles maintains axonal mitochondrial homeostasis and prevents axonal degeneration

R De Pace, S Ghosh, VH Ryan, M Sohn, M Jarnik… - Nature …, 2024 - nature.com
In neurons, RNA granules are transported along the axon for local translation away from the
soma. Recent studies indicate that some of this transport involves hitchhiking of RNA …

Quality control of orphaned proteins

S Juszkiewicz, RS Hegde - Molecular cell, 2018 - cell.com
The billions of proteins inside a eukaryotic cell are organized among dozens of sub-cellular
compartments, within which they are further organized into protein complexes. The …

Ribosome biogenesis: An emerging druggable pathway for cancer therapeutics

F Catez, N Dalla Venezia, V Marcel, C Zorbas… - Biochemical …, 2019 - Elsevier
Ribosomes are nanomachines essential for protein production in all living cells. Ribosome
synthesis increases in cancer cells to cope with a rise in protein synthesis and sustain …

On-site ribosome remodeling by locally synthesized ribosomal proteins in axons

T Shigeoka, M Koppers, HHW Wong, JQ Lin… - Cell reports, 2019 - cell.com
Ribosome assembly occurs mainly in the nucleolus, yet recent studies have revealed robust
enrichment and translation of mRNAs encoding many ribosomal proteins (RPs) in axons, far …

Endosymbiotic selective pressure at the origin of eukaryotic cell biology

PK Raval, SG Garg, SB Gould - Elife, 2022 - elifesciences.org
The dichotomy that separates prokaryotic from eukaryotic cells runs deep. The transition
from pro-to eukaryote evolution is poorly understood due to a lack of reliable intermediate …