Drugs targeting structural and nonstructural proteins of the chikungunya virus: A review

M Wang, L Wang, P Leng, J Guo, H Zhou - International Journal of …, 2024 - Elsevier
Chikungunya virus (CHIKV) is a single positive-stranded RNA virus of the Togaviridae family
and Alphavirus genus, with a typical lipid bilayer envelope structure, and is the causative …

Inflammatory Effects of Bothrops Phospholipases A2: Mechanisms Involved in Biosynthesis of Lipid Mediators and Lipid Accumulation

V Moreira, E Leiguez, PM Janovits, R Maia-Marques… - Toxins, 2021 - mdpi.com
Phospholipases A2s (PLA2s) constitute one of the major protein groups present in the
venoms of viperid and crotalid snakes. Snake venom PLA2s (svPLA2s) exhibit a remarkable …

Chikungunya virus entry is strongly inhibited by phospholipase A2 isolated from the venom of Crotalus durissus terrificus

IA Santos, JF Shimizu, DM de Oliveira, DOS Martins… - Scientific Reports, 2021 - nature.com
Chikungunya virus (CHIKV) is the etiologic agent of Chikungunya fever, a globally
spreading mosquito-borne disease. There is no approved antiviral or vaccine against …

Proteomic identification and quantification of snake venom biomarkers in venom and plasma extracellular vesicles

NK Willard, E Salazar, FA Oyervides, CS Wiebe… - Toxins, 2021 - mdpi.com
The global exploration of snakebites requires the use of quantitative omics approaches to
characterize snake venom as it enters into the systemic circulation. These omics approaches …

Cytosolic phospholipase A2-α participates in lipid body formation and PGE2 release in human neutrophils stimulated with an L-amino acid oxidase from Calloselasma …

MV Paloschi, JA Lopes, CN Boeno, MDS Silva… - Scientific Reports, 2020 - nature.com
Cr-LAAO, an l-amino acid oxidase isolated from Calloselasma rhodosthoma snake venom,
has been demonstrated as a potent stimulus for neutrophil activation and inflammatory …

Crotalus Durissus Ruruima: Current Knowledge on Natural History, Medical Importance, and Clinical Toxinology

MB Pucca, PS Bernarde, AM Rocha, PF Viana… - Frontiers in …, 2021 - frontiersin.org
Crotalus durissus ruruima is a rattlesnake subspecies mainly found in Roraima, the
northernmost state of Brazil. Envenomings caused by this subspecies lead to severe clinical …

[HTML][HTML] Action of BjussuMP-II, a snake venom metalloproteinase isolated from Bothrops jararacussu venom, on human neutrophils

K Lisita, MDS Silva, HM Santana, YJ Ikenohuchi… - Toxicon, 2023 - Elsevier
Snake venom metalloproteinases (SVMPs) are enzymatic proteins present in large amounts
in snake venoms presenting proteolytic, hemorrhagic, and coagulant activities. BjussuMP-II …

Biological and Medical Aspects Related to South American Rattlesnake Crotalus durissus (Linnaeus, 1758): A View from Colombia

CA Cañas - Toxins, 2022 - mdpi.com
In Colombia, South America, there is a subspecies of the South American rattlesnake
Crotalus durissus, C. d. cumanensis, a snake of the Viperidae family, whose presence has …

Emerging anticancer potential and mechanisms of snake venom toxins: A review

X Guo, Y Fu, J Peng, Y Fu, S Dong, RB Ding… - International Journal of …, 2024 - Elsevier
Animal-derived venom, like snake venom, has been proven to be valuable natural resources
for the drug development. Previously, snake venom was mainly investigated in its …

[HTML][HTML] Comparative Analysis of the Enzymatic, Coagulant, and Neuromuscular Activities of Two Variants of Crotalus durissus ruruima Venom and Antivenom …

PJ Demico, IN Oliveira, VS Proença-Hirata, SR Dias… - Pharmaceuticals, 2025 - mdpi.com
Background: We compared the enzymatic, coagulant, and neuromuscular activities of two
variants (yellow—CDRy and white—CDRw) of Crotalus durissus ruruima venom with a …