In this short review, we give an overview of microtubule nucleation within cells. It is nearly 30
years since the discovery of γ-tubulin, a member of the tubulin superfamily essential for …

As one of four filament types, microtubules are a core component of the cytoskeleton and are
essential for cell function. Yet how microtubules are nucleated from their building blocks, the …

Organization of microtubule arrays requires spatio-temporal regulation of the microtubule
nucleator γ-tubulin ring complex (γTuRC) at microtubule organizing centers (MTOCs). MTOC …

The ability to switch a gene from off to on and monitor dynamic changes provides a powerful
approach for probing gene function and elucidating causal regulatory relationships. Here …

Microtubule (MT) filaments, composed of α/β-tubulin dimers, are fundamental to cellular
architecture, function and organismal development. They are nucleated from MT organizing …

Centrosomes are a functionally conserved feature of eukaryotic cells that play an important
role in cell division. The conserved γ-tubulin complex organizes spindle and astral …

Microtubules are major constituents of the cytoskeleton in all eukaryotic cells. They are
essential for chromosome segregation during cell division, for directional intracellular …

Understanding how cellular functions emerge from the underlying molecular mechanisms is
a key challenge in biology. This will require computational models, whose predictive power …

Microtubule (MT) nucleation is regulated by the γ-tubulin ring complex (γTuRC), conserved
from yeast to humans. In Saccharomyces cerevisiae, γTuRC is composed of seven identical …

The γ-tubulin ring complex (γ-TuRC) is a structural template for controlled nucleation of
microtubules from α/β-tubulin heterodimers. At the cytoplasmic side of the yeast spindle pole …