[HTML][HTML] Osteoarthritis year in review 2024: Epidemiology and therapy

A Courties, I Kouki, N Soliman, S Mathieu… - Osteoarthritis and …, 2024 - Elsevier
Abstract This" Year in Review" presents a curated selection of research themes and
individual studies within the clinical osteoarthritis (OA) field, focusing on epidemiology and …

Understanding and controlling the variables for stromal vascular fraction therapy

N Jeyaraman, S Shrivastava, VR Ravi… - World Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
In regenerative medicine, the isolation of mesenchymal stromal cells (MSCs) from the
adipose tissue's stromal vascular fraction (SVF) is a critical area of study. Our review …

A phase I dose-escalation clinical trial to assess the safety and efficacy of umbilical cord-derived mesenchymal stromal cells in knee osteoarthritis

J Matas, C García, D Poblete, R Vernal… - Stem Cells …, 2024 - academic.oup.com
Osteoarthritis (OA) is the most common degenerative joint disease. Mesenchymal stromal
cells (MSC) are promising cell-based therapy for OA. However, there is still a need for …

From dysfunction to healing: advances in mitochondrial therapy for Osteoarthritis

M Zhang, J Wu, K Cai, Y Liu, B Lu, J Zhang… - Journal of Translational …, 2024 - Springer
Osteoarthritis (OA) is a chronic degenerative joint condition characterised by cartilage
deterioration and changes in bone morphology, resulting in pain and impaired joint mobility …

Human adipose and synovial-derived MSCs synergistically attenuate osteoarthritis by promoting chondrocyte autophagy through FoxO1 signaling

J Wu, S Huang, Y Yu, Q Lian, Y Liu, W Dai… - Stem Cell Research & …, 2024 - Springer
Background Human adipose-derived stem cells (ADSCs) exert a strong anti-inflammatory
effect, and synovium-derived stem cells (SDSCs) have high chondrogenic potential. Thus …

[HTML][HTML] Human Infrapatellar Fat Pad Mesenchymal Stem Cell–derived Extracellular Vesicles Purified by Anion Exchange Chromatography Suppress Osteoarthritis …

Q Liu, J Wu, H Wang, Z Jia, G Li - Clinical Orthopaedics and …, 2024 - journals.lww.com
Background Extracellular vesicles derived from mesenchymal stem cells (MSCs) show great
promise in treating osteoarthritis (OA). However, studies from the perspective of clinical …

[PDF][PDF] Conservative and Emerging Rehabilitative Approaches for Knee Osteoarthritis Management

TA Addissouky, IE El Sayed, MM Ali - J Clinical Orthopaedics and …, 2024 - researchgate.net
Background: Knee osteoarthritis (OA) involves complex interactions between biological and
biomechanical factors that drive joint degeneration. Conservative rehabilitation approaches …

Clinical updates in mesenchymal stromal cell therapy for osteoarthritis treatment

GI Im - Expert Opinion on Biological Therapy, 2024 - Taylor & Francis
Introduction Osteoarthritis (OA) is a common chronic musculoskeletal disease with
heterogeneous clinical manifestations and variable responses to different treatments …

[HTML][HTML] Decadal analysis of efficacy and safety profiles of mesenchymal stem cells from varied sources in knee osteoarthritis patients: A systematic review and …

X Tang, H Huang, L Hao - Experimental Gerontology, 2024 - Elsevier
Abstract Objective Knee Osteoarthritis (KOA) is a debilitating degenerative joint ailment
afflicting millions of patients. Numerous studies have assessed the efficacy of mesenchymal …

[PDF][PDF] Multiomics analyses reveal adipose-derived stem cells inhibit the inflammatory response of M1-like macrophages through secreting lactate

T Horie, H Hirata, T Sakamoto, H Kitajima… - Stem Cell Research & …, 2024 - Springer
Background Adipose-derived stem cells (ADSCs) are widely used in the field of regenerative
medicine because of their various functions, including anti-inflammatory effects. ADSCs are …