Human organotypic and organoid cultures provide increasingly life‐like models of
tissue/organ development and disease, enable more realistic drug screening, and may …

Mammalian and bacterial cells sense and exert mechanical forces through the process of
mechanotransduction, which interconverts biochemical and physical signals. This is …

Significant changes in cell stiffness, contractility, and adhesion, ie, mechanotype, are
observed during a variety of biological processes. Whether cell mechanics merely change …

During the growth of a cell collective, such as proliferating microbial colonies and epithelial
tissues, the local cell growth increases the local pressure, which in turn suppresses cell …

Numerous methods have been reported for the fabrication of 3D multi-cellular spheroids and
their use in stem cell culture. Current methods typically relying on the self-assembly of …

Cell adhesion-mediated piezoelectric stimulation provides a noninvasive method for in situ
electrical regulation of cell behavior, offering new opportunities for the design of smart …

Mechanical properties of the extracellular matrix (ECM) critically regulate a number of
important cell functions including growth, differentiation and migration. Type I collagen and …

Within a purely mechanical setting, we investigate the behavior, up to full decohesion, of a
system modeling the interactions exchanged between focal adhesions and extra-cellular …

Hydrogel biomaterials in combination with living cells are applied in cell biology, tissue
engineering and regenerative medicine. In particular, poly (acrylamide)(PAM) hydrogels are …

Mechanical forces are key regulators of cell and tissue physiology. The basic molecular
mechanism of fiber contraction by the sliding of actin filament upon myosin leading to …