Cell type-specific gene expression relies on transcription factors (TFs) binding DNA
sequence motifs embedded in chromatin. Understanding how motifs are accessed in …

Cells utilize diverse ATP-dependent nucleosome-remodelling complexes to carry out
histone sliding, ejection or the incorporation of histone variants, suggesting that different …

Advances in genomics technology have provided the means to probe myriad chromatin
interactions at unprecedented spatial and temporal resolution. This has led to a profound …

The packaging of DNA into chromatin in eukaryotes regulates gene transcription, DNA
replication and DNA repair. ATP-dependent chromatin remodelling enzymes (re) arrange …

Nucleosomes cover most of the genome and are thought to be displaced by transcription
factors in regions that direct gene expression. However, the modes of interaction between …

Cells must tightly regulate their gene expression programs and yet rapidly respond to acute
biochemical and biophysical cues within their environment. This information is transmitted to …

Chromatin remodelers regulate genes by organizing nucleosomes around promoters, but
their individual contributions are obfuscated by the complex in vivo milieu of factor …

The estrogen receptor (ER), glucocorticoid receptor (GR), and forkhead box protein 1
(FoxA1) are significant factors in breast cancer progression. FoxA1 has been implicated in …

CRISPR screens have been used to connect genetic perturbations with changes in gene
expression and phenotypes. Here we describe a CRISPR-based, single-cell combinatorial …

The classic view of nucleosome organization at active promoters is that two well-positioned
nucleosomes flank a nucleosome-depleted region (NDR). However, this view has been …