Neurobiology of chronic mild stress: parallels to major depression
MN Hill, KGC Hellemans, P Verma, BB Gorzalka… - Neuroscience & …, 2012 - Elsevier
The chronic mild (or unpredictable/variable) stress (CMS) model was developed as an
animal model of depression more than 20 years ago. The foundation of this model was that …
animal model of depression more than 20 years ago. The foundation of this model was that …
Discovering imaging endophenotypes for major depression
G Hasler, G Northoff - Molecular psychiatry, 2011 - nature.com
Psychiatry research lacks an in-depth understanding of mood disorders phenotypes, leading
to limited success of genetics studies of major depressive disorder (MDD). The dramatic …
to limited success of genetics studies of major depressive disorder (MDD). The dramatic …
A sex-specific genome-wide association study of depression phenotypes in UK Biobank
PP Silveira, I Pokhvisneva, DM Howard… - Molecular …, 2023 - nature.com
There are marked sex differences in the prevalence, phenotypic presentation and treatment
response for major depression. While genome-wide association studies (GWAS) adjust for …
response for major depression. While genome-wide association studies (GWAS) adjust for …
Ketamine-induced reduction in mGluR5 availability is associated with an antidepressant response: an [11C] ABP688 and PET imaging study in depression
The mechanisms of action of the rapid antidepressant effects of ketamine, an N-methyl-D-
aspartate glutamate receptor antagonist, have not been fully elucidated. This study …
aspartate glutamate receptor antagonist, have not been fully elucidated. This study …
Androgen-dependent excitability of mouse ventral hippocampal afferents to nucleus accumbens underlies sex-specific susceptibility to stress
Background Depression affects women nearly twice as often as men, but the
neurobiological underpinnings of this discrepancy are unclear. Preclinical studies in male …
neurobiological underpinnings of this discrepancy are unclear. Preclinical studies in male …
Metabotropic glutamate receptor ligands as possible anxiolytic and antidepressant drugs
Depression and anxiety represent a major problem. However, the current treatment of both
groups of diseases is not satisfactory. As the glutamatergic system may play an important …
groups of diseases is not satisfactory. As the glutamatergic system may play an important …
Mood disorders: regulation by metabotropic glutamate receptors
Medicinal therapies for mood disorders neither fully serve the efficacy needs of patients nor
are they free of side-effect issues. Although monoamine-based therapies are the primary …
are they free of side-effect issues. Although monoamine-based therapies are the primary …
Antidepressant-like effects of mGluR1 and mGluR5 antagonists in the rat forced swim and the mouse tail suspension tests
Drugs that act to reduce glutamatergic neurotransmission such as NMDA receptor
antagonists exert antidepressant-like effects in a variety of experimental paradigms, but their …
antagonists exert antidepressant-like effects in a variety of experimental paradigms, but their …
Is subcortical–cortical midline activity in depression mediated by glutamate and GABA? A cross-species translational approach
A Alcaro, J Panksepp, J Witczak, DJ Hayes… - Neuroscience & …, 2010 - Elsevier
Major depressive disorder has recently been characterized by abnormal resting state
hyperactivity in anterior midline regions. The neurochemical mechanisms underlying resting …
hyperactivity in anterior midline regions. The neurochemical mechanisms underlying resting …
Association between chronic stress-induced structural abnormalities in Ranvier nodes and reduced oligodendrocyte activity in major depression
S Miyata, M Taniguchi, Y Koyama, S Shimizu… - Scientific reports, 2016 - nature.com
Repeated stressful events are associated with the onset of major depressive disorder
(MDD). We previously showed oligodendrocyte (OL)-specific activation of the …
(MDD). We previously showed oligodendrocyte (OL)-specific activation of the …