Mechanisms of autoantibody-induced pathology

RJ Ludwig, K Vanhoorelbeke, F Leypoldt… - Frontiers in …, 2017 - frontiersin.org
Autoantibodies are frequently observed in healthy individuals. In a minority of these
individuals, they lead to manifestation of autoimmune diseases, such as rheumatoid arthritis …

Pemphigoid diseases

E Schmidt, D Zillikens - The Lancet, 2013 - thelancet.com
Pemphigoid diseases are a group of well defined autoimmune disorders that are
characterised by autoantibodies against structural proteins of the dermal–epidermal junction …

Epidermolysis bullosa acquisita: the 2019 update

H Koga, C Prost-Squarcioni, H Iwata… - Frontiers in …, 2019 - frontiersin.org
Epidermolysis bullosa acquisita (EBA) is an orphan autoimmune disease. Patients with EBA
suffer from chronic inflammation as well as blistering and scarring of the skin and mucous …

Clinical features and diagnosis of epidermolysis bullosa acquisita

A Vorobyev, RJ Ludwig, E Schmidt - Expert review of clinical …, 2017 - Taylor & Francis
Introduction: Epidermolysis bullosa acquisita (EBA) is a rare autoimmune blistering disease
of skin and mucous membranes. EBA is caused by autoantibodies against type VII collagen …

[HTML][HTML] Epidermolysis bullosa acquisita: from pathophysiology to novel therapeutic options

M Kasperkiewicz, CD Sadik, K Bieber… - Journal of Investigative …, 2016 - Elsevier
Epidermolysis bullosa acquisita (EBA) is a prototypic organ-specific autoimmune disease
induced by autoantibodies to type VII collagen causing mucocutaneous blisters. In the …

Regulation of antibody effector functions through IgG Fc N-glycosylation

I Quast, B Peschke, JD Lünemann - Cellular and molecular life Sciences, 2017 - Springer
Immunoglobulin gamma (IgG) antibodies are key effector proteins of the immune system.
They recognize antigens with high specificity and are indispensable for immunological …

Clinical presentation, pathogenesis, diagnosis, and treatment of epidermolysis bullosa acquisita

RJ Ludwig - International Scholarly Research Notices, 2013 - Wiley Online Library
Epidermolysis bullosa acquisita (EBA) is a chronic mucocutaneous autoimmune skin
blistering disease. The pathogenic relevance of autoantibodies targeting type VII collagen …

Impact of serum cytokine levels on EEG-measured arousal regulation in patients with major depressive disorder and healthy controls

FM Schmidt, A Pschiebl, C Sander, KC Kirkby… - …, 2016 - karger.com
Background: In major depressive disorder (MDD), findings include hyperstable regulation of
brain arousal measured by electroencephalography (EEG) vigilance analysis and …

EndoS and EndoS2 hydrolyze Fc-glycans on therapeutic antibodies with different glycoform selectivity and can be used for rapid quantification of high-mannose …

J Sjögren, EFJ Cosgrave, M Allhorn, M Nordgren… - …, 2015 - academic.oup.com
Enzymes that affect glycoproteins of the human immune system, and thereby modulate
defense responses, are abundant among bacterial pathogens. Two endoglycosidases from …

The carbohydrate switch between pathogenic and immunosuppressive antigen‐specific antibodies

M Collin, M Ehlers - Experimental dermatology, 2013 - Wiley Online Library
IgG antibodies have one conserved N‐glycosylation site at Asn 297 in each of their constant
heavy chain regions. These Fc glycans influence the overall structure and pro‐or anti …