The scientific community is increasingly concerned with the proportion of published
“discoveries” that are not replicated in subsequent studies. The field of rodent behavioral …

Ageing is a process that gradually increases the organism's vulnerability to death. It affects
different biological pathways, and the underlying cellular mechanisms are complex. In view …

The number of people aged over 65 is expected to double in the next 30 years. For many,
living longer will mean spending more years with the burdens of chronic diseases such as …

Dysregulation of splicing factor expression and altered alternative splicing are associated
with aging in humans and other species, and also with replicative senescence in cultured …

The lifespan of mice shows genotype, sex and laboratory effects, but little is known about
genotype or sex differences in life expectancy of mouse models of Alzheimer's disease (AD) …

Transient receptor potential (TRP) proteins TRPM6 and TRPM7 are α-kinase-coupled
divalent cation-selective channels activated upon a reduction of cytosolic levels of Mg 2+ …

Age is the leading risk factor for prevalent diseases and death. However, the relation
between age-related physiological changes and lifespan is poorly understood. We …

Sex and age influence susceptibility to acute kidney injury (AKI), with young females
exhibiting lowest incidence. In these studies, we investigated mechanisms which may …

Epidemiological studies of human longevity found two interesting features, robust advantage
of female lifespan and consistent reduction of lifespan variation. To help understand the …

Age is the single greatest risk factor for many diseases, including oral diseases. Despite this,
a majority of preclinical oral health research has not adequately considered the importance …