Oncogenic activation of the phosphatidylinositol-3-kinase (PI3K), protein kinase B
(PKB/AKT), and mammalian target of rapamycin (mTOR) pathway is a frequent event in …

Androgen deprivation therapy (ADT) and androgen receptor (AR)-targeted therapy are the
gold standard options for treating prostate cancer (PCa). These are initially effective, as …

The phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway regulates multiple cellular
processes. An overactivation of the pathway is frequently present in human malignancies …

Rational target therapy of cancer would benefit from the identification of new targets that can
be easily inhibited by small molecules. An increasing amount of evidence hints at 3 …

Kinome-wide profiling platforms have comprehensively identified the relevant kinases that
are targeted by numerous protein kinase inhibitors. However, recent projects have begun to …

Although 3-phosphoinositide–dependent protein kinase-1 (PDK1) has been predominately
linked to the phosphoinositide 3-kinase (PI3K)–AKT pathway, it may also evoke additional …

Three theories of regeneration dominate neuroscience today, all purporting to explain why
the adult central nervous system (CNS) cannot regenerate. One theory proposes that Nogo …

There is great interest in developing selective protein kinase inhibitors by targeting allosteric
sites, but these sites often involve protein–protein or protein–peptide interfaces that are very …

The ability of cells to migrate is essential for different physiological processes including
embryonic development, angiogenesis, tissue repair and immune response. In the context of …

Because malignant cells have altered, usually accelerated, energy consumption, targeting
metabolic signaling represents a prevailing strategy for tumor therapy. Phosphoinositide …