Targeting the immune microenvironment for ovarian cancer therapy

F Blanc-Durand, L Clemence Wei Xian… - Frontiers in …, 2023 - frontiersin.org
Ovarian cancer (OC) is an aggressive malignancy characterized by a complex
immunosuppressive tumor microenvironment (TME). Immune checkpoint inhibitors have …

Immunotherapeutic approaches in ovarian cancer

H Yoon, A Kim, H Jang - Current Issues in Molecular Biology, 2023 - mdpi.com
Ovarian cancer (OC) is gynecological cancer, and diagnosis and treatment are continuously
advancing. Next-generation sequencing (NGS)-based diagnoses have emerged as novel …

Nanotechnology for boosting ovarian cancer immunotherapy

P Kaur, SK Singh, MK Mishra, S Singh… - Journal of Ovarian …, 2024 - Springer
Ovarian cancer, often referred to as the “silent killer,” is notoriously difficult to detect in its
early stages, leading to a poor prognosis for many patients. Diagnosis is often delayed until …

Dendritic cells in cancer immunology and immunotherapy

L Hato, A Vizcay, I Eguren, JL Pérez-Gracia… - Cancers, 2024 - mdpi.com
Simple Summary Although immune check point inhibitors have been established as a new
paradigm in cancer treatment, they have shown no clinical benefit in immune excluded or …

Regulatory effects of IRF4 on immune cells in the tumor microenvironment

J Lu, T Liang, P Li, Q Yin - Frontiers in immunology, 2023 - frontiersin.org
The tumor microenvironment (TME) is implicated in tumorigenesis, chemoresistance,
immunotherapy failure and tumor recurrence. Multiple immunosuppressive cells and soluble …

Limitations and potential of immunotherapy in ovarian cancer

S Kumar, S Acharya, M Karthikeyan, P Biswas… - Frontiers in …, 2024 - frontiersin.org
Ovarian cancer (OC) is the third most common gynecological cancer and alone has an
emergence rate of approximately 308,069 cases worldwide (2020) with dire survival rates …

A review of the clinical experience with CMN-001, a tumor RNA loaded dendritic cell immunotherapy for the treatment of metastatic renal cell carcinoma

M DeBenedette, A Gamble, M Norris… - Human Vaccines & …, 2023 - Taylor & Francis
Engineering dendritic cells (DCs) to treat cancer is a long sought-after goal for cell-based
immunotherapies. In this review, we focus on the experience with CMN-001, formally AGS …

[HTML][HTML] Dendritic cells in triple-negative breast cancer: From pathophysiology to therapeutic applications

AI Sebastião, G Simões, F Oliveira, D Mateus… - Cancer Treatment …, 2025 - Elsevier
Breast cancer is the second most commonly diagnosed cancer in women and the fifth
leading cause of cancer-related deaths worldwide. It is a highly heterogeneous disease …

Trial watch: anticancer vaccination with dendritic cells

F Borges, RS Laureano, I Vanmeerbeek… - …, 2024 - Taylor & Francis
Dendritic cells (DCs) are critical players at the intersection of innate and adaptive immunity,
making them ideal candidates for anticancer vaccine development. DC-based …

Role of Biofunctionalized Nanoparticles in Digestive Cancer Vaccine Development

R Zdrehus, C Delcea, L Mocan - Pharmaceutics, 2024 - mdpi.com
Nanotechnology has provided an opportunity for unparalleled development of the treatment
of various severe diseases. The unique properties of nanoparticles offer a promising …