Single‐Layered MoS2–PEI–PEG Nanocomposite‐Mediated Gene Delivery Controlled by Photo and Redox Stimuli

J Kim, H Kim, WJ Kim - Small, 2016 - Wiley Online Library
Stimuli‐responsive gene delivery systems maximize therapeutic efficacy by controlling the
cytosolic conveyance and rate of effective gene release. We present herein a hybrid …

Small molecule activators of the heat shock response: chemical properties, molecular targets, and therapeutic promise

JD West, Y Wang, KA Morano - Chemical research in toxicology, 2012 - ACS Publications
All cells have developed various mechanisms to respond and adapt to a variety of
environmental challenges, including stresses that damage cellular proteins. One such …

An injectable and physical levan-based hydrogel as a dermal filler for soft tissue augmentation

WI Choi, Y Hwang, A Sahu, K Min, D Sung, G Tae… - Biomaterials …, 2018 - pubs.rsc.org
The use of injectable materials as a biofiller for soft tissue augmentation has been
increasing worldwide. Levan is a biocompatible and inexpensive polysaccharide with great …

Structural topologies involving energetically significant antiparallel π-stacking and unconventional N (nitrile)⋯ π (fumarate) contacts in dinuclear Zn (ii) and polymeric …

P Sharma, T Baishya, RM Gomila, A Frontera… - New Journal of …, 2022 - pubs.rsc.org
Two new poly-nuclear coordination compounds of Zn (II) and Mn (II) viz.[Zn2 (male) 2 (3-
AMpy) 4]· 3H2O (1) and [Mn (H2O) 2 (μ-fum)(3-CNpy) 2] n (2)(male= maleate, fum …

Strain‐Promoted Azide–Alkyne Cycloaddition with Ruthenium (II)–Azido Complexes

T Cruchter, K Harms, E Meggers - Chemistry–A European …, 2013 - Wiley Online Library
The reactivity of an exemplary ruthenium (II)–azido complex towards non‐activated, electron‐
deficient, and towards strain‐activated alkynes at room temperature and low millimolar azide …

Supramolecular assemblies involving biologically relevant antiparallel π-stacking and unconventional solvent driven structural topology in maleato and fumarato …

A Das, P Sharma, A Frontera, M Barcelo-Oliver… - New Journal of …, 2021 - pubs.rsc.org
Two new coordination polymers of Zn (II), viz.{[Zn (Hdmpz) 2 (μ-male)]·(MeOH)(H2O)} n (1)
and [Zn (3-AMpy) 2 (μ-fum)(H2O) 2] n (2)(where Hdmpz= 3, 5-dimethylpyrazole, male …

Visualization of Modified Bisarylbutadiyne-Tagged Small Molecules in Live-Cell Nuclei by Stimulated Raman Scattering Microscopy

M Kawaguchi, Y Yonetani, T Mizuguchi… - Analytical …, 2024 - ACS Publications
Visualizing the distribution of small-molecule drugs in living cells is an important strategy for
developing specific, effective, and minimally toxic drugs. As an alternative to fluorescence …

Hsp72 is an intracellular target of the α, β-unsaturated sesquiterpene lactone, parthenolide

M Shin, A McGowan, GJ DiNatale… - ACS …, 2017 - ACS Publications
The electrophilic natural product parthenolide has generated significant interest as a model
for potential chemotherapeutics. Similar to other α, β-unsaturated carbonyl electrophiles …

Enhanced toxicity of the protein cross-linkers divinyl sulfone and diethyl acetylenedicarboxylate in comparison to related monofunctional electrophiles

JD West, CE Stamm, HA Brown… - Chemical research in …, 2011 - ACS Publications
Previously, we determined that diethyl acetylenedicarboxylate (DAD), a protein cross-linker,
was significantly more toxic than analogous monofunctional electrophiles. We hypothesized …

Identification of a potent Nrf2 displacement activator among aspirin-containing prodrugs

IN Gaisina, DM Hushpulian, AM Gaisin… - Neurochemistry …, 2021 - Elsevier
Aspirin is a desired leaving group in prodrugs aimed at treatment of neurodegeneration and
other conditions. A library of aspirin derivatives of various scaffolds potentially activating Nrf2 …