The concept of geroscience is that since ageing is the greatest risk factor for many diseases
and conditions, targeting the ageing process itself will have the greatest impact on human …

Mitochondria are one of the organelles undergoing rapid alteration during the senescence
process. Senescent cells show an increase in mitochondrial size, which is attributed to the …

Mitochondria are one of organelles that undergo significant changes associated with
senescence. An increase in mitochondrial size is observed in senescent cells, and this …

Cellular senescence is a crucial process of irreversible cell-cycle arrest, in which cells
remain alive, but permanently unable to proliferate in response to distinct types of stressors …

Increasing evidence suggests a strong interplay between autophagy and genomic stability.
Recently, several papers have demonstrated a molecular connection between the DNA …

Oxidative stress is a primary cause of cellular senescence and contributes to the etiology of
numerous human diseases. Oxidative damage to telomeric DNA has been proposed to …

In humans, aging is characterized by a gradual decline of physical and psychological
functions, with the concomitant onset of chronic-degenerative diseases, which ultimately …

Human skin is composed of three layers: the epidermis, the dermis, and the hypodermis.
The epidermis has four major cell layers made up of keratinocytes in varying stages of …

Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disorder caused by
the expression of progerin, a mutant variant of Lamin A. Recently, HGPS studies have …

Aging is considered the main risk factor for many chronic diseases that frequently appear at
advanced ages. However, the inevitability of this process is being questioned by recent …