Engineering considerations to produce bioactive compounds from plant cell suspension culture in bioreactors

EA Motolinía-Alcántara, CO Castillo-Araiza… - Plants, 2021 - mdpi.com
The large-scale production of plant-derived secondary metabolites (PDSM) in bioreactors to
meet the increasing demand for bioactive compounds for the treatment and prevention of …

Verbascoside: comprehensive review of a phenylethanoid macromolecule and its journey from nature to bench

R Saha, A Majie, R Baidya, B Sarkar - Inflammopharmacology, 2024 - Springer
Polyphenolic compounds are among the most widely researched compounds for various
therapeutic applications. However, naturally occurring phenylethanoid glycosides are least …

Antioxidant Potential and Enhancement of Bioactive Metabolite Production in In Vitro Cultures of Scutellaria lateriflora L. by Biotechnological Methods

I Kwiecień, N Miceli, M D'Arrigo, A Marino, H Ekiert - Molecules, 2022 - mdpi.com
Studies carried out using three different in vitro assays and a biological setting (Escherichia
coil) demonstrated the antioxidant activity of Scutellaria lateriflora microshoot extract …

Different Types of Hypericum perforatum cvs. (Elixir, Helos, Topas) In Vitro Cultures: A Rich Source of Bioactive Metabolites and Biological Activities of Biomass …

I Kwiecień, N Miceli, E Kędzia, E Cavò, MF Taviano… - Molecules, 2023 - mdpi.com
Microshoot agitated and bioreactor cultures (PlantForm bioreactors) of three Hypericum
perforatum cultivars (Elixir, Helos, Topas) were maintained in four variants of Murashige and …

Bioproduction process of natural products and biopharmaceuticals: Biotechnological aspects

I Süntar, S Çetinkaya, ÜS Haydaroğlu… - Biotechnology …, 2021 - Elsevier
Decades of research have been put in place for developing sustainable routes of
bioproduction of high commercial value natural products (NPs) on the global market. In the …

Synergistic effect of polyphenol-rich complex of plant and green propolis extracts with antibiotics against respiratory infections causing bacteria

A Ramata-Stunda, Z Petriņa, V Valkovska… - Antibiotics, 2022 - mdpi.com
Bacterial infections are a prevalent complication after primary viral respiratory infections and
are associated with high morbidity and mortality. Antibiotics are widely used against …

The pro-differentiating capability of a flavonoid-rich extract of Citrus bergamia juice prompts autophagic death in THP-1 cells

L Musumeci, C Russo, U Schumacher… - Scientific Reports, 2024 - nature.com
Acute myeloid leukemia (AML) is a hematologic neoplasm, characterized by a blockage of
differentiation and an unconstrained proliferation of immature myeloid cells. Recently, the …

Toxicological evaluation of ginsenoside-rich cell culture biomass of Panax japonicus produced in a large-scale bioreactor system

MV Titova, EV Popova, IM Ivanov, AA Fomenkov… - Industrial Crops and …, 2024 - Elsevier
An environmentally friendly, resource-efficient substitute for the production of vegetative
biomass and the bioactive components of medicinal plants is provided by novel …

The Inhibition of Mitogen-Activated Protein Kinases (MAPKs) and NF-κB Underlies the Neuroprotective Capacity of a Cinnamon/Curcumin/Turmeric Spice Blend in Aβ …

A Maugeri, C Russo, GT Patanè, D Barreca… - Molecules, 2023 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by an increased
level of β-amyloid (Aβ) protein deposition in the brain, yet the exact etiology remains elusive …

Suspension Cell Culture of Polyscias fruticosa (L.) Harms in Bubble-Type Bioreactors—Growth Characteristics, Triterpene Glycosides Accumulation and Biological …

MV Titova, DV Kochkin, ES Sukhanova, EN Gorshkova… - Plants, 2023 - mdpi.com
Polyscias fruticosa (L.) Harms, or Ming aralia, is a medicinal plant of the Araliaceae family,
which is highly valued for its antitoxic, anti-inflammatory, analgesic, antibacterial, anti …