The erythroid marrow and circulating red blood cells (RBCs) are the key components of the
human erythron. Abnormalities of the erythron that are responsible for anemia can be …

During erythropoiesis, there is an enormous demand for the synthesis of the essential
cofactor of hemoglobin, heme. Heme is synthesized de novo via an eight enzyme-catalyzed …

Coenzyme Q (CoQ, ubiquinone) is an essential cellular cofactor composed of a redox-active
quinone head group and a long hydrophobic polyisoprene tail. How mitochondria access …

Heme plays a central role in diverse, life-essential processes that range from ubiquitous,
housekeeping pathways such as respiration, to highly cell-specific ones such as oxygen …

X-linked sideroblastic anemia (XLSA) and X-linked protoporphyria (XLPP) are uncommon
diseases caused by loss-of-function and gain-of-function mutations, respectively, in the …

Given its remarkable property to easily switch between different oxidative states, iron is
essential in countless cellular functions which involve redox reactions. At the same time …

Purpose Uveal melanoma (UM) is adults' most common primary intraocular malignant tumor.
It has been observed that 40% of patients experience distant metastasis during subsequent …

Coenzyme Q (CoQ, ubiquinone) is an essential cellular cofactor comprised of a redox-active
quinone head group and a long hydrophobic polyisoprene tail. How mitochondria access …

Mutations in the SLC25A38 gene are responsible for the second most common form of
congenital sideroblastic anemia (CSA), a severe condition for which no effective treatment …

Diamond–Blackfan anemia (DBA) is a ribosomopathy characterized by bone marrow
erythroid hypoplasia, which typically presents with severe anemia within the first months of …