Clinical management of metastatic colorectal cancer in the era of precision medicine

F Ciardiello, D Ciardiello, G Martini… - CA: a cancer journal …, 2022 - Wiley Online Library
Colorectal cancer (CRC) represents approximately 10% of all cancers and is the second
most common cause of cancer deaths. Initial clinical presentation as metastatic CRC …

Secretome proteomics for discovery of cancer biomarkers

M Makridakis, A Vlahou - Journal of proteomics, 2010 - Elsevier
“Secretome” is referred to as the rich, complex set of molecules secreted from living cells. In
a less strict definition frequently followed in “secretome” studies, the term also includes …

Pericellular hydrogel/nanonets inhibit cancer cells

Y Kuang, J Shi, J Li, D Yuan, KA Alberti… - Angewandte Chemie …, 2014 - Wiley Online Library
Fibrils formed by proteins are vital components for cells. However, selective formation of
xenogenous nanofibrils of small molecules on mammalian cells has yet to be observed …

Furin‐instructed intracellular gold nanoparticle aggregation for tumor photothermal therapy

J Chen, Y Ma, W Du, T Dai, Y Wang… - Advanced Functional …, 2020 - Wiley Online Library
Today, exploring ideal photothermal agents (PTAs) for effective photothermal therapy (PTT)
of cancer is an important issue. Cancer‐related enzyme‐instructed aggregation of gold …

Cell environment-differentiated self-assembly of nanofibers

Z Zheng, P Chen, M Xie, C Wu, Y Luo… - Journal of the …, 2016 - ACS Publications
Employing cellular environment for the self-assembly of supramolecular nanofibers for
biological applications has been widely explored. But using one precursor to differentiate …

Extracellular matrix and colorectal cancer: how surrounding microenvironment affects cancer cell behavior?

S Crotti, M Piccoli, F Rizzolio… - Journal of cellular …, 2017 - Wiley Online Library
Colorectal cancer (CRC) whit more than a million of new cases per year is one of the most
common registered cancers worldwide with few treatment options especially for advanced …

Secreted proteins as a fundamental source for biomarker discovery

M Stastna, JE Van Eyk - Proteomics, 2012 - Wiley Online Library
The proteins secreted by various cells (the secretomes) are a potential rich source of
biomarkers as they reflect various states of the cells at real time and at given conditions. To …

EGLN1 inhibition and rerouting of α-ketoglutarate suffice for remote ischemic protection

BA Olenchock, J Moslehi, AH Baik, SM Davidson… - Cell, 2016 - cell.com
Ischemic preconditioning is the phenomenon whereby brief periods of sublethal ischemia
protect against a subsequent, more prolonged, ischemic insult. In remote ischemic …

Enzyme-instructed self-assembly for cancer therapy and imaging

BJ Kim, B Xu - Bioconjugate chemistry, 2020 - ACS Publications
Enzymatic reactions and self-assembly are two fundamental attributes of cells. It is not
surprising that one can use enzyme-instructed self-assembly (EISA)—the integration of …

Cross-tissue omics analysis discovers ten adipose genes encoding secreted proteins in obesity-related non-alcoholic fatty liver disease

N Darci-Maher, M Alvarez, UT Arasu, I Selvarajan… - …, 2023 - thelancet.com
Background Non-alcoholic fatty liver disease (NAFLD) is a fast-growing, underdiagnosed,
epidemic. We hypothesise that obesity-related inflammation compromises adipose tissue …