Addressing genetic tumor heterogeneity, post-therapy metastatic spread, cancer repopulation, and development of acquired tumor cell resistance
Simple Summary The present review summarizes and interprets uniform therapy schemes
for rescuing relapsed or refractory (r/r) neoplasias of quite different histologic origins …
for rescuing relapsed or refractory (r/r) neoplasias of quite different histologic origins …
Recent insights into the role of PPARs in disease
N Wagner, KD Wagner - Cells, 2023 - mdpi.com
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that play
important roles in cell proliferation, differentiation, metabolism, and cancer [1–5]. They were …
important roles in cell proliferation, differentiation, metabolism, and cancer [1–5]. They were …
Synthesis, molecular docking, and in vivo antidiabetic evaluation of new benzylidene-2, 4-thiazolidinediones as partial PPAR-γ agonists
Peroxisome proliferator-activated receptor-γ (PPAR-γ) partial agonists or antagonists, also
termed as selective PPAR-γ modulators, are more beneficial than full agonists because they …
termed as selective PPAR-γ modulators, are more beneficial than full agonists because they …
Integrated investigation and experimental validation of PPARG as an oncogenic driver: implications for prognostic assessment and therapeutic targeting in …
Y Ran, C Hu, J Wan, Q Kang, R Zhou, P Liu… - Frontiers in …, 2023 - frontiersin.org
Peroxisome proliferator-activated receptor gamma (PPARG), a key transcription factor
involved in lipid metabolism and glucose homeostasis, has been implicated in various types …
involved in lipid metabolism and glucose homeostasis, has been implicated in various types …
Oxidative Stress and the Nrf2/PPARγ Axis in the Endometrium: Insights into Female Fertility
P Artimovič, Z Badovská, S Toporcerová, I Špaková… - Cells, 2024 - mdpi.com
Successful pregnancy depends on precise molecular regulation of uterine physiology,
especially during the menstrual cycle. Deregulated oxidative stress (OS), often influenced by …
especially during the menstrual cycle. Deregulated oxidative stress (OS), often influenced by …
Cancer Cell-Intrinsic Alterations Associated with an Immunosuppressive Tumor Microenvironment and Resistance to Immunotherapy in Lung Cancer
N Otegui, M Houry, I Arozarena, D Serrano, E Redin… - Cancers, 2023 - mdpi.com
Simple Summary Immunotherapy for non-small cell lung cancer (NSCLC) is a clinical reality
with impressive efficacy for some patients. However, less than half of them will benefit from …
with impressive efficacy for some patients. However, less than half of them will benefit from …
Repurposed Drugs Celecoxib and Fmoc-L-Leucine Alone and in Combination as Temozolomide-Resistant Antiglioma Agents—Comparative Studies on Normal and …
Ł Uram, N Pieńkowska, M Misiorek… - International Journal of …, 2024 - mdpi.com
Glioblastoma multiforme therapy remains a significant challenge since there is a lack of
effective treatment for this cancer. As most of the examined gliomas express or overexpress …
effective treatment for this cancer. As most of the examined gliomas express or overexpress …
Structural Studies on the Binding Mode of Bisphenols to PPARγ
Bisphenol A (BPA) and bisphenol B (BPB) are widely used in the production of plastics, and
their potential adverse health effects, particularly on endocrine disruption and metabolic …
their potential adverse health effects, particularly on endocrine disruption and metabolic …
PPARγ Modulators in Lung Cancer: Molecular Mechanisms, Clinical Prospects, and Challenges
Lung cancer is one of the most lethal malignancies worldwide. Peroxisome proliferator-
activated receptor gamma (PPARγ, NR1C3) is a ligand-activated transcriptional factor that …
activated receptor gamma (PPARγ, NR1C3) is a ligand-activated transcriptional factor that …
[HTML][HTML] Thiazolidinedione an Auspicious Scaffold as PPAR-γ Agonist: its Possible Mechanism to Manoeuvre against Insulin Resistant Diabetes Mellitus.
S Basak, A Murmu, BW Matore, PP Roy… - European Journal of …, 2024 - Elsevier
Thiazolidinedione (TZD) plays a crucial role in activating PPAR-γ receptor, which helps to
inhibit insulin-resistant Diabetes Mellitus through binding with DNA by forming a complex …
inhibit insulin-resistant Diabetes Mellitus through binding with DNA by forming a complex …