Heparin characterization: challenges and solutions
CJ Jones, S Beni, JFK Limtiaco… - Annual review of …, 2011 - annualreviews.org
Although heparin is an important and widely prescribed pharmaceutical anticoagulant, its
high degree of sequence microheterogeneity and size polydispersity make molecular-level …
high degree of sequence microheterogeneity and size polydispersity make molecular-level …
Hyphenated techniques for the analysis of heparin and heparan sulfate
B Yang, K Solakyildirim, Y Chang… - Analytical and bioanalytical …, 2011 - Springer
The elucidation of the structure of glycosaminoglycan has proven to be challenging for
analytical chemists. Molecules of glycosaminoglycan have a high negative charge and are …
analytical chemists. Molecules of glycosaminoglycan have a high negative charge and are …
Insights into the mechanism of separation of heparin and heparan sulfate disaccharides by reverse-phase ion-pair chromatography
CJ Jones, N Membreno, CK Larive - Journal of Chromatography A, 2010 - Elsevier
Reverse-phase ion-pair high performance liquid chromatography (RPIP-HPLC) and ultra-
performance liquid chromatography (RPIP-UPLC) are increasingly popular chromatographic …
performance liquid chromatography (RPIP-UPLC) are increasingly popular chromatographic …
Characterization of heparin impurities with HPLC-NMR using weak anion exchange chromatography
JFK Limtiaco, CJ Jones, CK Larive - Analytical chemistry, 2009 - ACS Publications
A weak anion exchange (WAX) chromatography method coupled to online UV and NMR
detection was developed for the separation and structural identification of heparin impurities …
detection was developed for the separation and structural identification of heparin impurities …
Understanding the effect of the counterion on the reverse-phase ion-pair high-performance liquid chromatography (RPIP-HPLC) resolution of heparin-related …
Reverse-phase ion-pair high-performance liquid chromatography (RPIP-HPLC) is an
increasingly popular chromatographic technique for the separation of charged compounds …
increasingly popular chromatographic technique for the separation of charged compounds …
Determination of galactosamine impurities in heparin samples by multivariate regression analysis of their 1H NMR spectra
Q Zang, DA Keire, RD Wood, LF Buhse… - Analytical and …, 2011 - Springer
Heparin, a widely used anticoagulant primarily extracted from animal sources, contains
varying amounts of galactosamine impurities. Currently, the United States Pharmacopeia …
varying amounts of galactosamine impurities. Currently, the United States Pharmacopeia …
Insights into the Capillary Electrophoresis Separation of Heparin Disaccharides from Nuclear Magnetic Resonance, pKa, and Electrophoretic Mobility Measurements
SL Eldridge, LA Higgins, BJ Dickey… - Analytical …, 2009 - ACS Publications
Determination of the p K a values of heparin disaccharide functional groups can provide
insights into the nature of glycosaminoglycan (GAG)− protein interactions and prove useful …
insights into the nature of glycosaminoglycan (GAG)− protein interactions and prove useful …
The efficient structure elucidation of minor components in heparin digests using microcoil NMR
JFK Limtiaco, S Beni, CJ Jones, DJ Langeslay… - Carbohydrate …, 2011 - Elsevier
The structural complexity and microheterogeneity of the glycosaminoglycans heparin and
heparan sulfate make their characterization a daunting task. The methodology described …
heparan sulfate make their characterization a daunting task. The methodology described …
Screening enoxaparin tetrasaccharide SEC fractions for 3-O-sulfo-N-sulfoglucosamine residues using [1H,15N] HSQC NMR
CN Beecher, MS Manighalam, AF Nwachuku… - Analytical and …, 2016 - Springer
Heparin and heparan sulfate (HS) are important in mediating a variety of biological
processes through binding to myriad different proteins. Specific structural elements along …
processes through binding to myriad different proteins. Specific structural elements along …
[PDF][PDF] The methods of assessment of quality and safety of medicaments on the basis of low molecular weight heparins
EA Arianova, MN Bogachuk… - Sechenov Medical …, 2022 - sechenovmedj.com
МЕТОДЫ ОЦЕНКИ КАЧЕСТВА И БЕЗОПАСНОСТИ ЛЕКАРСТВЕННЫХ СРЕДСТВ НА ОСНОВ
Page 1 20 СЕЧЕНОВСКИЙ ВЕСТНИК № 3 (5)–4 (6) 2011 г. УДК 615.013+615.074 ББК 52.81 …
Page 1 20 СЕЧЕНОВСКИЙ ВЕСТНИК № 3 (5)–4 (6) 2011 г. УДК 615.013+615.074 ББК 52.81 …