The incidence of necrotising soft-tissue infections has increased during recent decades such
that most physicians might see at least one case of these potentially life-threatening …

Streptococcus pyogenes, also known as group A Streptococcus (GAS), causes mild human
infections such as pharyngitis and impetigo and serious infections such as necrotizing …

Abstract Background. Invasive group A Streptococcus (GAS) infections are associated with
significant morbidity and mortality rates. We report the epidemiology and trends of invasive …

Background Increases in invasive group A streptococcal disease (iGAS) have recently been
reported in multiple countries in the northern hemisphere, occurring during, and outside of …

Streptococcus pyogenes is also known as group A Streptococcus (GAS) and is an important
human pathogen that causes considerable morbidity and mortality worldwide. The GAS …

Understanding immunity in humans to Group A Streptococcus (Strep A) is critical for the
development of successful vaccines to prevent the morbidity and mortality attributed to Strep …

Toxic shock syndrome (TSS) is an acute, multi-system, toxin-mediated illness, often resulting
in multi-organ failure. It represents the most fulminant expression of a spectrum of diseases …

Abstract Group A Streptococcus (GAS) infections result in a considerable underappreciated
burden of acute and chronic disease globally. A 2018 World Health Assembly resolution …

Background Necrotizing skin and soft-tissue infections (NSTI) are rare but potentially life-
threatening and disabling infections that often require intensive care unit admission …

Necrotising fasciitis (NF) is situated with myositis and myonecrosis at the severe end of a
spectrum of skin and soft tissue infections but is far removed from erisepelas, impetigo and …