In nature, the self-assembly of sequence-specific biopolymers into hierarchical structures
plays an essential role in the construction of functional biomaterials. To develop synthetic …

Unlike natural macromolecules (eg, nucleic acids and proteins) possessing precisely
defined molar mass, chain sequence, chirality, and topology, synthetic polymers are typically …

The breadth of structure and function displayed by the molecules of biology is remarkable.
Considering that there are only three major biopolymer backbones (proteins, ribonucleic …

In recent years, our understanding of protein structure and function has advanced rapidly,
providing a mechanistic understanding of a wide variety of biological processes. As an …

Bioinspired polymeric materials are attracting increasing attention due to significant
advantages over their natural counterparts: the ability to precisely tune their structures over a …

In most general terms, polymers and their supramolecular assemblies have been defining
life on this planet since its conception. Polymers of nucleic acids carry the code of life and …

Antimicrobial peptides (AMPs) and their mimics are emerging as promising antibiotic agents.
We present a library of “ampetoids”(antimicrobial peptoid oligomers) with helical structures …

The highly refined organic chemistry in solid-phase synthesis has made it the method of
choice not only to assemble peptides but also small proteins–mainly on a laboratory scale …

We have synthesized and characterized a family of structured oligo-N-substituted-glycines
(peptoids) up to 36 residues in length by using an efficient solid-phase protocol to …

A series of peptoid oligomers were designed as helical, cationic, and facially amphipathic
mimics of the magainin-2 amide antibacterial peptide. We used circular dichroism …