Background Alzheimer's disease (AD), the most prevalent form of dementia, remains
enigmatic in its origins despite the widely accepted" amyloid hypothesis," which implicates …

Highlights•A one-stop platform for large-scale DIA, including diaPASEF metaproteomics
analysis.•metaExpertPro outperformed three other tools in peptide identifications from a …

Abstract Phosphodiesterase‐5 (PDE5) inhibitors are used clinically for the treatment of
erectile dysfunction, pulmonary arterial hypertension, and other urological diseases …

Identifying and treating lipid abnormalities is crucial for preventing cardiovascular disease in
diabetic patients, yet only two-thirds of patients reach recommended cholesterol levels …

Prediction of protein-ligand interaction is necessary for drug design, gene regulatory
networks investigation, and chemical probes detection. The existing methods commonly …

Obesity is a major public health concern and burden on individuals and healthcare systems.
Due to the challenges and limitations of lifestyle adjustments, it is advisable to consider …

Background and Objective: Alzheimer's disease (AD) as the most common
neurodegenerative disorder. Klotho is an anti-aging protein with important roles in …

Hyperlipidemia is a prevalent chronic metabolic disorder typically treated with statins, which
have significant limitations. Jasminum sambac (L.) Aiton Leaves (Jasmine Leaves), a …

The binary model of existence consists of health and disease, with health being complete
physical, mental, and social well-being and disease being a pathological process. Humanity …

Obesity prevalence increases worldwide. The most crucial reason for obesity is high-fat diet
(HFD). Serum fatty acid levels are increased with HFD, inducing inflammation and glucose …