Accumulation of deoxyribonucleic acid (DNA) damage diminishes cellular health, increases
risk of developmental and degenerative diseases, and accelerates aging. Optimizing …

Micronucleus (MN) analyses in peripheral blood lymphocytes and exfoliated cells from
different organs (mouth, nose, bladder and cervix) are at present the most widely used …

Deuterium is a non‐toxic, stable isotope that can safely be administered to humans and
mice to study their cellular turnover rates in vivo. It is incorporated into newly synthesized …

The thymus hosts the development of a specific type of adaptive immune cells called T cells.
T cells orchestrate the adaptive immune response through recognition of antigen by the …

Ambient particulate matter (PM) has gained significant attention as an environmental risk
factor for human health. Although the association between ambient PM and micronucleus …

Stable isotope labeling is a generally applicable method of quantifying cell dynamics. Its
advent has opened up the way for the quantitative study of T cells in humans. However, the …

Metabolism is a dynamic network of biochemical reactions that support systemic
homeostasis amidst changing nutritional, environmental, and physical activity factors. The …

Abstract Type 1 diabetes (T1D) mellitus is a systemic disease triggered by a local
autoimmune inflammatory reaction in insulin-producing cells that induce organ-wide, long …

Natural killer (NK) cells are innate lymphocytes that control tumor progression by not only
directly killing cancer cells, but also by regulating other immune cells, helping to orchestrate …

The processes governing lymphocyte fate (division, differentiation, and death), are typically
assumed to be independent of cell age. This assumption has been challenged by a series of …