Mitochondria are major sources of reactive oxygen species (ROS) within the cell and are
especially vulnerable to oxidative stress. Oxidative damage to mitochondria results in …

Hypometabolism, characterized by decreased brain glucose consumption, is a common
feature of many neurodegenerative diseases. Initial hypometabolic brain state, created by …

Epilepsy is a central nervous system disorder involving spontaneous and recurring seizures
that affects 50 million individuals globally. Because approximately one-third of patients with …

Although the mechanisms underlying the anti-seizure effects of the high-fat ketogenic diet
(KD) remain unclear, a long-standing question has been whether ketone bodies (ie, β …

Animal models of epilepsy and seizures, mostly involving mice and rats, are used to
understand the pathophysiology of the different forms of epilepsy and their comorbidities, to …

Background Hippocampal damage caused by status epilepticus (SE) can bring about
cognitive decline and emotional disorders, which are common clinical comorbidities in …

Epilepsy is a common chronic neurological disorder in modern society. One of the major
unmet challenges is that current antiseizure medications are basically not disease …

Prolonged severe hypoxia follows brief seizures and represents a mechanism underlying
several negative postictal manifestations without interventions. Approximately 50% of the …

The present study was aimed at analyzing the effects of physical exercise on mitochondrial
physiology, anxio-depressive-like behaviors and neuroplasticity in mice. Adult C57BL/6J …

The ketogenic diet (KD) is an effective therapy primarily used in pediatric patients whom are
refractory to current anti-seizure medications. The mechanism of the KD is not completely …