The self controlled case series (SCCS) method is an epidemiological study design for which
individuals act as their own control—ie, comparisons are made within individuals. Hence …

OBJECTIVE: Large health care utilization databases are frequently used in variety of
settings to study the use and outcomes of therapeutics. Their size allows the study of …

Background: The BNT162b2 (Pfizer–BioNTech) vaccine has been shown to be safe with
regard to risk for severe cardiovascular events (such as myocardial infarction [MI] …

Background The time stratified case cross-over approach is a popular alternative to
conventional time series regression for analysing associations between time series of …

Background There is evidence that chronic inflammation may promote atherosclerotic
disease. We tested the hypothesis that acute infection and vaccination increase the short …

Background: Long-term use of oral corticosteroids has known adverse effects, but the risk
from brief oral steroid bursts (≤ 14 days) is largely unknown. Objective: To examine the …

Background After the introduction of an inactivated intranasal influenza vaccine that was
used only in Switzerland, 46 cases of Bell's palsy were reported. Methods We conducted a …

Background We undertook an epidemiological study to investigate whether measles,
mumps, and rubella (MMR) vaccine may be causally associated with autism. Methods …

▪ Abstract The first decade of experience with case-crossover studies has shown that the
design applies best if the exposure is intermittent, the effect on risk is immediate and …

Drug discovery and development affects various aspects of human health and dramatically
impacts the pharmaceutical market. However, investments in a new drug often go …